Searchable abstracts of presentations at key conferences in endocrinology

ea0028p243 | Pituitary | SFEBES2012

Acute Management of Pituitary Apoplexy: Experience in 70 consecutive cases

Jose Biju , Pelluri Lavanya , Mitchell Rosalind , Gittoes Neil , Ayuk John

Introduction: Pituitary apoplexy is an uncommon medical emergency with a reported incidence in pituitary adenomas of 2–7%. UK guidelines on the management of pituitary apoplexy have recently been published. On this background we analysed the management of pituitary apoplexy at a single tertiary centre.Methods: A retrospective analysis was performed to evaluate clinical presentation, management and clinical outcomes in a cohort of patients, who prese...

ea0015p377 | Thyroid | SFEBES2008

TSH-secreting pituitary adenoma (TSH-oma) with coexistent autoimmune hypothyroidism

Rangan Srinivasa , Karamat Muhammad , Mitchell Rosalind , Gittoes Neil , Franklyn Jayne

A 69-year-old man with no family history of thyroid disease presented with weight gain and constipation. He was clinically euthyroid with no goitre. Investigations confirmed autoimmune hypothyroidism with FT4 16.9 pmol/l (N: 10–22), TSH 29.14 mIU/l (N: 0.4–4.5), elevated thyroid peroxidase (TPO) antibodies 3311 IU/ml (N: 0–34) and he was commenced on thyroxine with serial dose adjustments to 250 mcg OD over 2 years. His TSH however remained ...

ea0034p287 | Pituitary | SFEBES2014

An evolution of clinical practice: the impact of changes in clinical management of non-functioning pituitary adenomas on long-term pituitary function and risk of recurrence

O'Reilly Michael , Pearce Harriet , Bugg Gabriella , Mitchell Rosalind , Toogood Andy , Gittoes Neil , Ayuk John

Management of newly-diagnosed non-functioning pituitary adenomas (NFPAs) has evolved over the last decade. Whilst surgical debulking remains the mainstay of treatment for patients presenting with compressive disease, the use of pituitary irradiation has declined, with greater emphasis on observation or further surgical debulking. We aimed to compare outcomes of treatment for NFPAs at our institution since 2004 with older management strategies.We reviewed...

ea0015p251 | Pituitary | SFEBES2008

Metastatic deposits from a pituitary adenoma 36 years after an initial presentation

Karamat Muhammad Ali , Rangan Srinivasan , Ayuk John , Mitchell Rosalind , Gittoes Neil

Pituitary carcinoma is rare and diagnosis requires demonstration of cerebrospinal and/or systemic metastasis. We present case of a 64-year-old lady who presented with widespread spinal metastasis from a pituitary adenoma diagnosed 36 years ago. Our patient presented in 1971 with visual failure, headache and oligomenorrhoea. Imaging confirmed pituitary macroadenoma and she underwent transcranial hypophysectomy. Histology revealed chromophobe adenoma. Post operatively her vision...

ea0049gp180 | Pituitary | ECE2017

Outcome of non-functioning pituitary adenomas that regrow after primary treatment: a study from two large specialist UK centers

Tampourlou Metaxia , Ntali Georgia , Ahmed Shahzada , Arlt Wiebke , Ayuk John , Byrne James , Chavda Swarupsinh , Cudlip Simon , Gittoes Neil , Grossman Ashley , Mitchell Rosalind , O'Reilly Michael , Paluzzi Alessandro , Toogood Andrew , Wass John , Karavitaki Niki

Introduction: Despite the significant risk of regrowth of non-functioning pituitary adenomas (NFAs) after primary treatment, systematic data on the probability of further tumour progression and the effectiveness of management approaches are lacking.Aims: Assess the probability of further regrowth(s), predictive factors and outcomes of management approaches in patients with NFA diagnosed with adenoma regrowth after primary treatment (surgery combined or n...