Searchable abstracts of presentations at key conferences in endocrinology

ea0019p155 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

7-Oxysterols are metabolised by 11ß-hydroxysteroid dehydrogenase-1 within the aortic wall but do not directly influence contractility

Mitic T , Walker BR , Andrew R , Hadoke PWF

Recent investigations have suggested that 11ß-hydroxysteroid dehydrogenase-1 (11ßHSD1) activity influences development of atherosclerotic lesions and that pharmacological inhibition of this enzyme may have therapeutic benefits. Whilst these findings have been attributed to glucocorticoid metabolism, 11ßHSD1 also inter-converts 7-oxysterols (oxidized products of cholesterol which may promote atherogenesis). This study investigates whether metabolism of 7-oxystero...