Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp23 | Calcium and Bone 1 | ECE2019

Study of hsa-miR-30e miRNA as a biomarker in identifying multiple gland disease in sporadic primary hyperparathyroidism: Is it time for individualized molecular-based surgery?

Mizamtsidi Maria , Nastos Konstantinos , Palazzo Fausto , Constantinides Vasilis , Dina Roberto , Farenden Megan , Vassiliou Ioannis , Gazouli Maria

Introduction: Sporadic primary hyperparathyroidism (sporadic PHPT) is a common endocrine disorder, usually caused by a single parathyroid adenoma. However, up to 15% of patients present with multiple gland disease (MGD), which cannot be always diagnosed preoperatively, raising serious management problems. No predictive genetic screening tests are currently available to distinguishing adenomas from MGD in sporadic PHPT. MiRNAs are widely established as genetic molecules that ha...

ea0032p78 | Bone and Osteoporosis | ECE2013

Effects of Denosumab treatment on insulin resistance in postmenopausal women with osteoporosis

Tzioras Konstantinos , Mizamtsidi Maria , Chronaiou Aikaterini , Vasiliou Georgia , Tagara Sofia , Vryonidou Andromachi

Introduction: Denosumab is a new pharmacotherapy option for postmenopausal osteoporosis. It is a human monoclonal antibody against RANKL, acting as an osteoprotegerin (OPG) analog. Recently, osteoprotegerin levels were found to be elevated in type two diabetes while insulin resistance was shown to be positively associated with decreased serum OPG levels, in healthy obese subjects. However, no study has been conducted in order to clarify the effect of anti-RANKL factors adminis...

ea0041gp219 | Thyroid Cancer | ECE2016

Prognostic factors for tumor invasiveness in papillary thyroid microcarcinomas

Polymeris Antonios , Mizamtsidi Maria , Travlos Alexis , Katsoulis Georgios , Dimitropoulou Fotini , Dermentzoglou Alexandros , Kalogeris Nikolaos , Tzioras Constantinos , Vryonidou Andromachi

Introduction: Papillary thyroid microcarcinomas (PTMC) are usually considered low-risk tumors with favorable prognosis. However, a small percentage behaves aggressively and controversies exist for various prognostic factors. The aim of this study was to evaluate demographic and tumor specific characteristics related to PTMC invasiveness.Patients – methods: This is a retrospective study of 510 thyroidectomized patients with PTMC who were treated in t...

ea0044oc1.3 | Early Career Oral Communications | SFEBES2016

Investigating the interaction between KNDy peptides on gonadotrophin release in humans – novel findings with therapeutic importance

Narayanaswamy Shakunthala , Prague Julia K , Jayasena Channa N , Papadopoulou Deborah A , Mizamtsidi Maria , Shah Amar J , Bassett Paul , Comninos Alexander N , Abbara Ali , Bloom Stephen R , Veldhuis Johannes D , Dhillo Waljit S

Background: Hypothalamic KNDy neurons have recently been identified as key regulators of reproductive function by releasing three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin. Animal studies show they interact to control pulsatile GnRH release, which is vital for fertility. In animals, kisspeptin stimulates, NKB modulates and the opioid dynorphin inhibits GnRH pulsatility. However, the interaction of these peptides has never been studied in humans. To inve...