Searchable abstracts of presentations at key conferences in endocrinology

ea0029p931 | Female Reproduction | ICEECE2012

Conformational control of P450aromatase by lipid membrane interactions and protein associations

Martin L. , Praporski S. , Rodgers R. , Corbin C. , Conley A. , Mizrachi D.

Cytochrome P450 aromatase is a membrane bound enzyme that synthesises estrogens. This reaction involves electron delivery from NADPH via cytochrome P450 reductase (CPR). Little is known as to how the P450arom performs the aromatase reaction or how it associates with CPR in the endoplasmic reticulum (ER). In humans, there is only one P450arom, however pigs have three isozymes. The catalytic efficiency of one of these, the porcine gonadal P450arom, is much lower than the human a...