Searchable abstracts of presentations at key conferences in endocrinology

ea0019p147 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Effect of pre and postnatal diet on pancreatic beta-cell insulin and glucagon content

Lloyd L , Mobasheri A , Gardner D

Insulin resistance is associated with obesity, metabolic syndrome and hypertension. These risk factors for type 2 diabetes and cardiovascular disease may be programmed by the early diet. Previous studies have shown poor insulin sensitivity in obese relative to lean sheep. Here, we considered whether insulin sensitivity in pre- and postnatally nutritionally challenged sheep offspring was due to changes at the pancreatic level. Thirty-six twin-bearing ewes were randomly allocate...