Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep693 | Pituitary: basic and neuroendocrinology | ECE2015

Fenofibrate has differential effects on cell proliferation and GH secretion in GH3 cells

Rotondi Sandra , Modarelli Alessio , Sanita Patrizia , Angelucci Adriano , Jaffrain-Rea Marie-Lise

We have recently observed that the peroxisome proliferator receptor α was expressed by normal and tumoural pituitary tissues, in particular by somatotrophs. To elucidate its function, we have studied the effects of fenofibrate on cell proliferation and GH secretion in GH3 cells.Material and methods: GH3 cells were grown in Ham’s F10 and treated for 24, 48 and 72 h by different concentrations of fenofibrate (12.5–50 &#...

ea0037ep694 | Pituitary: basic and neuroendocrinology | ECE2015

Single dose irradiation of GH3 cells increase GH and PRL secretion in vitro

Fratticci Amato , Rotondi Sandra , Modarelli Alessio , Bonfili Pierluigi , Cesare Ernesto Di , Alesse Edoardo , Jaffrain-Rea Marie-Lise

Radiotherapy (RT) may represent a useful tool in the treatment of GH-secreting tumours in the presence of a post-operative active disease and single dose stereotactic RT/gamma knife is the preferred option in most cases. The effects of RT on the control of hormone secretion are very slow and pharmacological treatment remains necessary for years. Some authors advocate withdrawal of somatostatin analogues (SSA) during RT, although the short-term effects of RT on hormone secretio...

ea0035p834 | Pituitary Basic (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Expression of peroxisome-proliferator activated receptor α in pituitary tumours

Rotondi Sandra , Modarelli Alessio , Rostomyan Lilya , Oliva Maria Antonietta , Esposito Vincenzo , Ventura Luca , Arcella Antonietta , Alesse Edoardo , Beckers Albert , Jaffrain-Rea Marielise

Peroxisome-proliferator activated receptors (PPARs) are involved in a number of neoplasia. PPARα (PPARα) is a partner of the aryl hydrocarbon receptor interacting protein (AIP), which is involved in the pathogenesis of pituitary adenomas (PA). We wished to investigate the potential expression and biological significance of PPARα in PA, especially in GH/PRL-secreting tumours.Material and methods: A large series of PA was collected (n</e...