Endocrine Abstracts

Non-functioning pituitary adenomas (NFPAs), mainly gonadotroph pituitary adenomas (GPAs), are the second most common type of PAs. Given the lack of symptoms secondary to hormone hypersecretion, NFPAs are often diagnosed when they cause mass effects. At this stage they are invasive (50% of cases), they cannot be completely resected and often recur. Despite their frequency, no standard of care drug treatment currently exists for these tumors. SSAs (somatostatin agonists) like oc...

Non-functioning pituitary neuroendocrine tumors (NF-PitNETs) are still orphan of medical therapy. The drmgs approved for the other types of PitNETs, e.g. somatostatin analogues (SSA) with high affinity for somatostatin receptors (SSTs) type 2 (SST2) and 5 (SST5) are poorly efficacious in NF-PitNETs. Among SSTs, NF-PitNETs express high levels of SST3, a receptor that can mediate antiproliferative and apoptotic signaling. ITF2984 is a pan-SST ligand with high affinity for SST3, ...