Searchable abstracts of presentations at key conferences in endocrinology

ea0072oc3 | Oral Communications | UKINETS2020

OMIC gene cluster evaluation amplifies the prognostic accuracy of the NETest

Kidd Mark , Kitz Alexandra , Drozdov Ignat , Modlin Irvin

Background: The NETest is a multi-gene assay comprising 51 circulating neuroendocrine tumor specific transcripts. The quotient of the 51-gene assay is based upon multi-algorithmic data analysis. Eight cancer hallmarks or ‘omes’ (apoptome, epigenome, growth factor signalome, metabolome, proliferome, plurome, secretome SSTRome) represent 29 genes. The NETest is an accurate diagnostic (>90%) but its prognostic utility has not been assessed. In this study, we describe ex...

ea0052p04 | (1) | UKINETS2017

A liquid biopsy for the diagnosis and monitoring of bronchopulmonary/lung carcinoid

Modlin Irvin M , Kidd Mark , Drozdov Ignat , Aslanian Harry , Bodei Lisa , Matar Somer , Chung Kjung-Min

Background: No effective blood biomarker exists to detect and clinically manage bronchopulmonary (BP) neuroendocrine tumors. We developed a blood-based 51 neuroendocrine tumor (NET)-specific transcript set to diagnose and monitor gastroenteropancreatic NETs. In this study, we examined whether the signature functioned in lung NETs. Thereafter, we examined performance metrics to assess clinical utility. The multianalyte gene signature accurately diagnosed the tumor and in additi...

ea0060p13 | (1) | UKINETS2018

Automated finger prick genomic diagnosis of neuroendocrine tumors

Modlin Irvin , Kidd Mark , Drozdov Ignat , Bodei Lisa , Malczewska Anna , Matar Somer , Chung Kyung-Min

Background: The diagnosis of neuroendocrine tumor disease has been tardy due to a lack of sensitive, noninvasive technology to facilitate identification. In the 1960’s, diagnosis required tumor tissue attained by surgery or biopsy. Identification was by histopathology and immunohistochemistry (1975). Acquisition of information was limited by the morbidity of invasive strategies, inability to reassess and interpretation was user-dependent with low kappa values. The introdu...

ea0025p173 | Endocrine tumours and neoplasia | SFEBES2011

Adenosine receptors modulate chromogranin A secretion and growth of neuroendocrine tumours: potential targets for therapy

Kalhan Atul , Garibi Borzo , Jasani Bharat , Kidd Mark , Modlin Irvin , Pfragner Roswitha , Rees Aled , Ham Jack

Introduction: Neuroendocrine tumors of GI tract are a heterogeneous group of rare neoplasms that secrete peptides and amines. These tumors are highly vascular and their vascularity reflects increased tumour related angiogenesis. Adenosine, a major regulator of angiogenesis, is released by enhanced degradation of ATP, during cellular stress, damage and hypoxia.Material and methods: The expression of adenosine receptors (AR) was investigated in two human n...

ea0052p03 | (1) | UKINETS2017

Blood measurements of Neuroendocrine Tumor (NET) transcripts and gene cluster analysis predict efficacy of PRRT

Bodei Lisa , van der Zwaan Wouter , Kidd Mark , Drozdov Ignat , Baum Richard P , Kwekkeboom Dik , Krenning Eric , Modlin Irvin M

Background: Peptide receptor radionuclide therapy (PRRT) is based on tumor somatostatin receptor (SSR) overexpression to deliver targeted isotope therapy. Functional imaging of SSR expression (SRE) is used as a predictor of efficacy, but there is no method to objectively predict PRRT efficacy. We report the efficacy of Predictive Quotient Index (PQI) to predict the utility of PPRT. PQI is derived from circulating NET transcript analysis (NETest) integrated with the tu...

ea0052p26 | (1) | UKINETS2017

Multi-parametric assessment improves prognostication of small bowel neuroendocrine neoplasms: external validation of the NET nomogram

Clift Ashley , Faiz Omar , Martin John , Wasan Harpreet , Liedke Marc-Olaf , Schloericke Erik , Malczewska Anna , Rindi Guido , Kidd Mark , Modlin Irvin , Frilling Andrea

Background: Small-bowel neuroendocrine tumours (SB-NET) commonly metastasise despite most being low grade. The NET nomogram developed, estimates 5- and 10-year survival in SB-NET by allocating scores for 15 clinicopathological parameters. We comparatively evaluated the prognostic power of this nomogram, the WHO/ENETS grading and AJCC/UICC staging systems.Methods: Patients with histologically-confirmed SB-NET were identified from databases at two tertiary...

ea0060p14 | (1) | UKINETS2018

Circulating neuroendocrine tumor gene expression is effective in monitoring peptide receptor radionuclide (PRRT) efficacy

Bodei Lisa , Kidd Mark , van der Zwan Wouter , Singh Aviral , Severi Stefano , Drozdov Ignat , Cwikla Jarowslaw , Kolasinska-Cwikla Agnieska , Baum Richard , Paganelli Giovanni , Krenning Eric , Modlin Irvin

Background: Predicting and monitoring PRRT is based upon NET overexpression of somatostatin receptor (SSR) to deliver targeted isotope therapy. Imaging SSR expression is ~60% accurate as a predictor of efficacy. However, it and other imaging modalities e.g., CT/MRI, have utility for monitoring response. Specific blood NET gene expression (Positive Predictor Quotient- [PPQ]) is accurate in predicting PRRT response (93–97%, Bodei et al. EJNMMI 2018). The utility of NET tran...

ea0052oc1 | (1) | UKINETS2017

A predictive quotient index, comprising neuroendocrine gene cluster analysis in blood and tissue grading is specifically predicts PRRT efficacy

Bodei Lisa , Kidd Mark , van der Zwaan Wouter , Singh Aviral , Severi Stefano , Drozdov Ignat , Kwekkeboom Dik , Cwikla Jaroslaw , Kolasinska-Cwikla Agnieska , Baum Richard P , Paganelli Giovanni , Krenning Eric , Modlin Irvin M

Background: The efficacy of PRRT is based upon NET over expression of somatostatin receptor (SSR) to deliver targeted isotope therapy. SSR expression (Krenning scale) compared to Predictive Quotient Index (PQI) (circulating NET transcript analysis mathematically integrated with grade) indicates the latter is more accurate for predicting PRRT efficacy. We evaluated whether PQI was specifically predictive or was prognostic for PRRT compared to other therapeutic strategi...

ea0052p02 | (1) | UKINETS2017

Validation of a blood biomarker test for the diagnosis and management of bronchopulmonary neuroendocrine tumors

Modlin Irvin , Kidd Mark , Lewczuk Anna , Chung Kjung-Min , Kolasinska-Cwikla Agnieska , Cwikla Jaroslaw , Lowczak Anna , Doboszynska Anna , Tesselaar Margot , Buikhuisen Wieneke , Malczewska Anna , Kos-Kudla Beata , Roffinella Matteo , Filosso Pier Luigi , Korse Tiny , Papotti Mauro , Bodei Lisa , Drozdov Ignat

Background: There is currently no effective blood biomarker for lung neuroendocrine neoplasia diagnosis and management. We describe the clinical utility of a 51 neuroendocrine-specific gene expression set in blood to diagnose bronchopulmonary neuroendocrine tumors (BPNETs) and define their clinical status.Methods: The discovery set included BPNETs (n=154) and controls (n=90), randomly assigned (1:1) to a test and validation set. Specifi...

ea0046p8 | (1) | UKINETS2016

Blood measurement of neuroendocrine gene transcripts defines the effectiveness of operative resection and ablation strategies

Modlin Irvin M , Frilling Andrea , Salem Ronald R , Alaimo Daniele , Drymousis Panagiotis , Wasan Harpreet S , Callahan Stephen , Faiz Omar , Weng Lei , Teixeira Nancy , Bodei Lisa , Drozdov Ignat , Kidd Mark

Background: Surgery is the only curative treatment for gastroenteropancreatic neuroendocrine tumors (GEP-NETs), but the prediction of residual disease/recurrence is limited in the absence of optimal biomarkers. We examined whether a blood-based multianalyte neuroendocrine gene transcript assay (NETest) would define tumor cytoreduction and therapeutic efficacy.Methods: The NETest is a polymerase chain reaction–based analysis of 51 genes. Disease acti...