Searchable abstracts of presentations at key conferences in endocrinology

ea0104p191 | Reproductive Endocrinology | SFEIES24

Impact of synthetic estrogen ethinylestradiol on endometrial morphology and function in diet-induced obese mice

Mc Guigan Orla , Sridhar Ananyaa , Khan Dawood , Flatt Peter R. , Moffett Charlotte R.

Background/aims: Obesity is a major risk factor for endometrial cancer with estrogens in combined oral contraceptives enhancing the severity of the disease. This study aims to explore the effect of synthetic estrogen ethinylestradiol (EE2) commonly used in oral contraceptives, on endometrial morphology and regulatory markers in diet-induced obese mice.Methods: Female TO mice were on a high-fat diet (HFD) for 27 weeks. Three groups (n = 5) were g...

ea0104oc9 | Oral Communications | SFEIES24

Pregnancy induced pancreatic islet expansion is compromised by consumption of cafeteria diet

Dubey Vaibhav , Tanday Neil , Irwin Nigel , Draper Matthew , Tarasov Andrei I. , Flatt Peter R. , Charlotte Moffett R

Background: Pregnancy induces pancreatic islet β-cell mass expansion, but the exact mechanisms responsible remain unclear. It is nevertheless believed that disturbances in the process contribute to the development of gestational diabetes. The current study investigates the impact of pregnancy and cafeteria diet on islet morphology, cellular proliferation/apoptosis as well as endocrine cell lineage plasticity. Methods: Non-pregnant and pregnant Ins<e...