Endocrine Abstracts

Non-islet cell tumour hypoglycaemia (NICTH) is a relatively rare form of hypoglycaemia affecting patients with solid tumours originating from mesenchymal and epithelial cells. The hypoglycaemia is due to the excessive secretion by these tumours of high molecular weight insulin-like growth factor (IGF)-2 or pro IGF-2 which stimulate the insulin receptor and suppresses GH secretion by negative feedback mechanism, resulting in hypoglycaemia. The causative tumours may present with...