Endocrine Abstracts

Gonadotropin-releasing hormone (GnRH) antagonists, primarily used in prostate cancer treatment, have found application in androgen-secreting ovarian tumors. Among these, degarelix, a pure GnRH antagonist was found to rapidly suppress testosterone levels within 24 h. Testosterone fell from 14 nM to 1.5 nM within 24 h and to less than 1 nM within 48 h. A 77-year-old woman presented with hirsutism and voice deepening over the past few months. Elevated serum testosterone levels wi...

Hashimoto’s thyroiditis is the most common cause of hypothyroidism in iodine-sufficient areas of the world, cause is thought to be a combination of genetic susceptibility and environmental factors. The pathology of the disease involves the formation of antithyroid antibodies that attack the thyroid tissue, causing progressive fibrosis. We present the case of a 38 year old male with history of hypertension, type 2 Diabetes and pre-existing hypothyroidism who presented with...