Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep1227 | Clinical Cases–Pituitary/Adrenal | ECE2015

Difficulties of acromegaly treatment in young patients: clinical case

Florescu Alexandru , Sandru Andra , Condrea Adrian , Moisii Liliana , Galesanu Corina

Transsphenoidal surgery still appears to be the best option for most of the patients with GH secreting adenomas. In many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Alternatives include medical therapy with somatostatin analogues, GH-receptor antagonists and dopamine agonists. These drugs can be used alone or in combination. Radiation therapy with conventional fractionated photons or radiosurgery with proton beam could also be eff...

ea0037ep1161 | Clinical Cases–Pituitary/Adrenal | ECE2015

Pasireotide - the last treatment option in Cushing's disease - case report

Galesanu Corina , Condrea Adrian , Niculescu Dan , Florescu Alexandru , Buzduga Catalin , Moisii Liliana , Ciubotaru Vasile

Introduction: The most common cause of Cushing’s disease is ACTH secreting tumours of the pituitary gland. It is associated with high morbidity and mortality. Pasireotide, a potential therapy, has a unique, broad somatostatin-receptor–binding profile, with high binding affinity for somatostatin-receptor subtype 5.Case report: We present the a 40-years-old man diagnosed in 2005 with Cushing’s Disease for which a left adrenalectomy was perfo...

ea0022p213 | Clinical case reports and clinical practice | ECE2010

The role of octreotide in the management of young patients with acromegaly

Florescu Alexandru , Grozavu Ilinka , Lisnic Natalia , Apostu Luminita , Moisii Liliana , Poeata Ion , Galesanu Corina

The last decade has provided major progress in the development of highly specific and selective pharmacological agents that have facilitated a more aggressive approach to the treatment of patients with acromegaly. Initial transsphenoidal surgery still appears to be the first line of treatment, but in many cases the biochemical cure targets are not reached and the patient needs adjuvant therapy. Somatostatin analogues have become the mainstay of the medical treatment of acromeg...

ea0014p500 | (1) | ECE2007

Short stature and neurofibromatosis type 1 – issues of diagnosis

Leustean Letitia , Hurjui Cristina , Preda Cristina , Vulpoi Carmen , Moisii Liliana , Zbranca Eusebie

Neurofibromatosis type 1 (NF1) is an inherited disorder characterized by formation of neurofibromas in the skin, brain and other parts of the body, in association with skin pigment changes. It is well known that this condition may be a risk factor for short stature with growth hormone deficiency (GHD) in children, due to suprasellar lesions. We present the case report of a 9-year-old boy admitted in our Service for short stature (-2DS). Physical examination revealed ‘caf&...

ea0022p212 | Clinical case reports and clinical practice | ECE2010

The difficulties of Cushing' s disease – case report

Grozavu Ilinka-Andreea , Florescu Alexandru , Lisnic Natalia , Apostu Luminita , Bostaca Tamara , Moisii Liliana , Niculescu Dan , Galesanu Corina

Cushing’s disease is relatively rare and affects most commonly adults aged 20 to 40. It is associated with high morbidity and mortality; early detection and diagnosis of Cushing’s disease may lead to decreased this two facts and improved quality of life.We present a 32-year-old man with abdominal purple striae, central obesity with typical ‘moon face’ and oscillatory blood pressure values.Hormonal exams revealed...