Endocrine Abstracts

Aim: Assess the effectiveness of management of pregnant women with type 1 diabetes mellitus (DM 1) with continuous subcutaneous insulin infusion (CSII).Materials and Methods: Pregnant women with DM 1 with CSII (n=21) - the main group and on multiple daily insulin injections (MDI) (n=216) - the comparison group. We used different models of the Medtronic pumps. The inclusion in the comparison group carried out by a continuous method. The ...

Our research focused on the role of immune mechanisms in diabetic foot ulcers development and impaired healing. The AIM of this study was to evaluate endogenous interleukin (IL1,4,6,8) production to the culture medium by the skin cells (keratinocytes and fibroblasts) cocultured with mononuclears of patients with type 2 diabetes mellitus (T2DM) and T2DM with chronic foot ulcers (DFU) in a 3D culture model.Materials and methods: A multilayer 3D immunocompe...

AimsDiabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD). Renal impairment may affect not only glycemic control, but also metabolism of biologically active cytokines such as adiponectin. Taking into account multiple effects of adiponectin the purpose of the study was to assess its changes in patients with type 1 diabetes (T1D) and comorbid CKD.Materials and methodsWe recruited 129 pati...

Background and Aims: to assess the relationship between level of interleukin-6 (IL-6) and the renal function in patients with diabetes mellitus (DM).Method: A total of 416 patients with DM, aged 34 to 75 years, were examined. Control group included 60 healthy patients the same age/All patients underwent standard clinical and laboratory examination, with an assessment of the levels of natriuretic peptides (BNP, proBNP) and level of IL-6. Renal function wa...

Pregnancy affects on the course type 1 diabetes (T1D), which is a result of changes in the production of hormones and their biorhythms.Aim: To examine circadian biorhythms of contrinsular hormones (BCh) contribution in the morning postprandial glycaemia depending on the type insulin therapy.Materials and methods: The study involved of 91 pregnant with T1D in 31–34 weeks on a background the maximum insulin resistance. Evaluatio...

Objective: Assessing the impact of glycaemic control on indicators of breathing during night sleep in type 1 diabetes patients.Methods: Continuous blood glucose monitoring by ‘SGMSGold’ (Medtronik MINIMED) with estimation of average glycaemic value (AG) and other parameters; polysomnographic monitoring by ‘SOMNOlab 2 (PSG) Polysomnography (R&K)’. Group 1 included patients with AG levels <8.0. Group 2: AG >8.0 mmol/l regard...

Background: The problem of iodine deficiency in Belarus remains topical, due to the historical understanding of iodine deficiency in the environment. As a result, the Republic of Belarus has developed and since 2000 implemented a strategy for iodine deficiency elimination, based on the use of iodized salt and food fortification.Aims: To determine iodine status in children living in Minsk region.Materials and methods: The study incl...

Background: Polymorphisms in angiotensin-converting enzyme (ACE) gene and angiotensin II type 1 receptor (AGTR1) gene have been assessed in previously multiple studies for association with diabetic nephropathy (DN), but results are still controversial.Aim: The aim of our study was to find out the role of ACE (I/D) and AGTR1 (A1166C) in genetic susceptibility of diabetic nephropathy in Belarusian population.Methods: The present case...

The efficiency of the Belarusian model for iodine deficiency elimination based on obligatory use of iodized salt in the industrial food production and bread baking has been often challenged in other countries. In support the facts are presented evidencing of insufficient iodine intake in groups of increased risk of iodine deficiency in children and pregnant women from the rural areas of Belarus. The goal of the recent study is to compare the dynamics of iodine supplementation ...

Introduction: Diabetes is the leading cause of chronic kidney disease (CKD) and is associated with excessive cardiovascular morbidity and mortality. On the other hand, anemia is common among those with diabetes and CKD and greatly contributes to patient outcomes.Aim: The aim of this study was to investigate the prevalence and associated risk factors of CKD among the patients with diabetes type 2 (DT2).Methods: We examined at baseli...