Searchable abstracts of presentations at key conferences in endocrinology

ea0022p492 | Female reproduction | ECE2010

Progesterone receptor signaling: new tricks from an old dog

Gracanin Ana , Sartorius Carol , Schoonen Willem , Mol Jan

Two progesterone receptor (PR) isoforms, the full-length PR-B and the N-terminally truncated PR-A, have distinct reproductive functions, with PR-B being required for a proper mammary gland development. The functional distinction between PR-B and PR-A has partially been attributed to the additional activation function (AF3) domain, localized within the PR-B-unique sequence (PR-BUS). Three highly conserved sequence motifs within AF3 domain are required for the strong transactiva...