Endocrine Abstracts

Background: Demeclocycline is a well-known treatment for syndrome of inappropriate ADH secretion (SIADH). We studied the use of demeclocycline for treatment of SIADH in our hospital to assess its efficacy and safety.Materials and methods: A search was performed for all discharge summaries containing demeclocycline over period of 1 year. 40 results obtained of which five were excluded as demeclocycline was mentioned but not actually used. 35 admission epi...

A 46 years old male with a background history of hypertension and asthma for which he was taking irbesartan and clenil inhaler respectively, was referred to the Endocrine service with a 3 weeks’ history of polyuria, polydipsia, nocturia and occasional headaches. On initial screening, diabetes mellitus and hypercalcemia were excluded. Initial biochemistry showed a sodium level was 144 mmol/l (135-144) with a serum osmolality of 300 mOsm/kg (275-295). A diagnosis of Diabete...

A 52 year old gentleman was referred for an inpatient Endocrinology review. He was admitted after incidental finding of severe hyponatremia of 119. He felt unwell after having an episode of vomiting at home a few days ago and then had his bloods done at primary care. He denied any headache, dizziness, or visual disturbance. Further investigations were requested which revealed plasma osm 247, urine osm 350, and urine sodium 132. A diagnosis of SIADH was established and he was p...

Introduction: Hyperthyroidism is a pathological state characterized by increased synthesis and secretion of thyroid hormones (thyroxine (T4) and triiodothyronine (T3)) by the thyroid gland. Subclinical hyperthyroidism – a milder form – is defined as a low or suppressed TSH (<0.4 mIU/l), but serum free T4 (FT4) and free T3 (FT3) within the reference interval.Case: 76 years old lady seen in endocrine clinic. She was referred by GP because of ...

Background: Postprandial hyperinsulinemic hypoglycaemia due to nesidioblastosis is a significant and debilitating complication after Roux-en-Y gastric bypass surgery (RYGB). There is growing evidence suggesting this is due to increased incretin hormones secretion. Nesidioblastosis can be difficult to manage with variable response to different pharmacological therapies and some requiring partial/total pancreatectomy or revision of bypass surgery pouch. We present a patient who ...

We present a case of 76-year-old male who attended acute medical unit with 3 week history of confusion, slurred speech and reduced mobility. One month prior to his admission he was diagnosed with severe hypothyroidism with TSH of 100 mU/l and T4 of 1.9 pmol/l and significantly positive anti-peroxidase antibodies (561 IU/ml) and was started on 100 μg of levothyroxine by his GP. During his admission his confusion persisted despite antibiotics for presumed chest i...

Introduction: Complete androgen insensitivity syndrome (CAIS) is an X-linked genetic disorder characterised by normal female appearance, including external genitalia and the presence of 46XY karyotype. We report a case of CAIS, diagnosed in adulthood, and discuss ethical issues surrounding the disclosure of diagnosis and associated difficulties in further management.Case history: A 33-year-old Nigerian lady was referred to our endocrine service with Prim...

Introduction: Phaeochromocytoma of the urinary bladder is a rare neoplasm and accounts for <1% of all phaeochromocytomas. It is more common in females and the majority of patients present in second and fourth decade. Its common presentation is painless haematuria, headache, palpitation, hypertension and syncope during or immediately after urination.Case history: We present a case of 48-year-old man who presented to Endocrinology with a few months his...

Functioning adrenal masses are often a diagnostic challenge and can present with unusual symptoms. We describe a case of a 37-year-old male with a background of ulcerative colitis, who presented with gynecomastia in the breast clinic. His serumbiochemistry showed persistently elevated Oestradiol and prolactin, with low testosterone and FSH. On physical examination, he had marked breast tenderness, bilateral gynecomastia and no signs of steroid excess. He reported a decline in ...

Introduction: Dermoid cysts are rare (0.5% of intracranial tumours). They are best considered a spectrum: from epidermoid cysts containing desquamated squamous epithelium to teratomas containing all three embryonic tissues. Sellar dermoid cysts are even rarer [Orpha.net ID: ORPHA:91351]. Case: A 47-year old white British male was referred following incidental discovery of bitemporal field defect on routine eye test. He was otherwise completely asymptomat...