Searchable abstracts of presentations at key conferences in endocrinology

ea0011p625 | Neuroendocrinology and behaviour | ECE2006

Dehydroepiandrosterone (DHEA) improves psychological well-being in male and female hypopituitary patients in addition to growth hormone replacement (GHR)

Brooke AM , Kalingag LA , Miraki-Moud F , Camacho-Hubner C , Maher KT , Walker DM , Hinson JP , Monson JP

Hypopituitarism is associated with profound androgen deficiency, even in patients who are adrenocorticotrophic hormone (ACTH) replete. DHEA has been shown to have a beneficial effect on well-being in patients with adrenal failure. We hypothesised that DHEA may be additive to the known effects of GH on psychological well-being in patients with hypopituitarism. In a double blind placebo controlled trial 50 mg DHEA or placebo was added to standard replacement, including growth ho...

ea0011p106 | Clinical case reports | ECE2006

Parathyroid carcinoma in multiple endocrine neoplasia (MEN) type 1: two case reports

Agha A , Carpenter R , Bhattacharya S , Monson JP

Hyperparathyroidism occurs in most patients with MEN Type 1 but the association of MEN type-1 with parathyroid carcinoma has only been described previously in one patient. In this report, we describe two further cases of parathyroid carcinoma presenting in association of MEN type 1 syndrome.The first patient was a 69-year-old woman who presented with severe hyperparathyroidism and tracheal compression by a mediastinal mass which was shown histologically ...

ea0011p92 | Clinical case reports | ECE2006

Purely adrenaline-secreting phaeochromocytoma: a classical presentation of a rare entity

Merghani A , Darzy KH , Morris D , Carpenter R , Deaner A , Monson JP

A provisional diagnosis of paroxysmal atrial fibrillation with normal blood pressure and echocardiogram was made in a 58 years old man. He described ‘funny turns’ on standing during which he would become sweaty, tremulous with palpitations and headache and facial flushing preceded by pallor. The patient was otherwise fit and healthy with a BMI of 27.3 kg/m2; he used to drink about 15 pints of beer per week and smoke 11 cigarettes daily for the last 40 year...

ea0015p221 | Pituitary | SFEBES2008

Gamma knife radiosurgery: a safe and effective treatment for acromegaly

Swords FM , Monson JP , Besser GM , Chew SL , Drake WM , Grossman AB , Plowman PN

We report the use of Gamma knife radiosurgery (GK) to 15 somatotroph adenomas. Eight patients had refractory acromegaly despite maximal conventional treatments: all had undergone conventional radiotherapy (CRT), mean interval between CRT and GK 15.6 years. Six had undergone surgery, two on more than one occasion. Five were receiving somatostatin analog therapy, one was receiving dopamine agonist therapy, one was on pegvisomant alone. All had radiologically defined disease, wel...

ea0011oc18 | Clinical endocrinology | ECE2006

Endoscope-assisted pituitary surgery for functioning and non-functioning pituitary adenomas. The experience of the first 80 patients in a single centre

Hanson PL , Joshi SM , Alusi G , Sabin HI , Drake WM , Monson JP

Introduction: We present the outcome for the first 80 patients undergoing neuronavigation–guided, endoscopic transphenoidal surgery in our centre since August 2001. All operations were undertaken by the same neurosurgeon and endoscopic nasal surgeon.Indications for treatment: Indications for treatment may be divided into: Functioning microadenomas, with the aim of surgical cure while protecting residual pituitary function. Functioning macroadenomas,...

ea0011p58 | Clinical case reports | ECE2006

Surgical management of metastatic phaeochromocytoma: review of 2 cases

El-Tawil TH , Darzy KH , Carpenter R , Bhattacharya S , Edmondson S , Monson JP

We report two cases of MIBG avid secretory phaeochromocytoma in 2 middle-aged ladies. Adrenalectomy, after standard preparation, was performed successfully and histology confirmed complete excision of a phaeochromocytoma in both cases; however, there was capsular infiltration and metastasis to a neighboring lymph node in the first case. In this case, surveillance CT scans 3 and 6 months later showed left adrenal bed recurrence and rapidly growing lesions in the right lobe of t...

ea0011p525 | Endocrine tumours and neoplasia | ECE2006

Investigation and surgical management of pancreatic neuroendocrine tumours

Coyle FM , Drake WM , Chew SL , Jenkins P , Hutchins RR , Grossman AB , Monson JP , Bhattacharya S

Introduction: Diagnosis of pancreatic neuroendocrine tumours (NETs) is often a challenge and involves biochemical characterisation and anatomic localisation of the tumour. Wherever feasible, curative surgical excision is the treatment of choice.Materials and Methods: Twenty four consecutive patients with pancreatic NETs were referred for consideration of surgery over a six-year period (1999–2005). Following use of multi imaging modalities to localis...

ea0011p855 | Thyroid | ECE2006

Unmasking of central hypothyroidism following growth hormone replacement in adult hypopituitary patients

Agha A , Walker D , Drake WM , Chew SL , Grossman AB , Jenkins PJ , Monson JP

The effect of growth hormone (GH) replacement on thyroid function in hypopituitary patients has only been studied in small groups of children and adults with conflicting results.We aimed to define the effect and clinical significance of adult GH replacement on thyroid status in a large cohort of 243 patients with hypopituitarism due to various causes. 84 patients were considered euthyroid before GH treatment and 159 patients had central hypothyroidism an...

ea0019p227 | Pituitary | SFEBES2009

Effect of the d3 growth hormone receptor genotype on GH responsiveness in adult hypopituitary patients

Moyes VJ , Walker D , Owusu-Antwi S , Maher KT , Metherell L , Akker SA , Monson JP , Clark AJ , Drake WM

Objective: Variability in growth hormone (GH) responsiveness is evident in adult hypopituitary patients receiving recombinant GH (rhGH). Doses vary up to 4-fold for unexplained reasons. Deletion of exon 3 in the GH receptor (d3-GHR) has been linked to an increased response to GH treatment in children, although data are conflicting. We investigated the role of the d3-GHR polymorphism in determining GH responsiveness in adult GH deficient patients.Methods:...

ea0012p11 | Clinical case reports/Governance | SFE2006

Sporadic pancreatic somatostatinomas: 3 cases

Brooke AM , Cheung TT , Metcalfe K , Carlsen E , Berney D , Bhattacharya S , Plowman PN , Monson JP , Drake WM

Sporadic somatostatinomas are rare neuroendocrine tumours (NETs), classically presenting with hyperglycaemia, cholelithiasis and steatorrhoea. The mainstay of treatment is surgical resection; other aspects of management remain uncertain. We report 3 cases. Case 1: A 55 year-old female presented with abdominal discomfort and steatorrhoea. Computed tomography (CT) demonstrated a 9 cm pancreatic mass. Biopsy suggested a NET. Somatostatin (SMS) was 160 pmol/l (normal 0-150)...