Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.04.08 | Steroids | ECE2015

Circadian variation in serum cortisol during hydrocortisone replacement is not attributable to changes in cortisol-binding globulin

Gunganah Kirun , Monson John , Drake William , Chung Teng Teng

Background: Patients taking hydrocortisone replacement for primary or secondary adrenal failure require individual adjustment of their dose. Previous observations in our department suggest that total serum cortisol levels achieved following an afternoon or evening dose of 5 mg hydrocortisone are almost as high as those that result from a 10 mg dose in the early morning; and that the ‘area under the cortisol curve’ (AUC) generated by an evening 5 mg dose is broader th...

ea0015oc17 | Tumours, diabetes, bone | SFEBES2008

Cinacalcet is an effective and well tolerated treatment for MEN1 associated primary hyperparathyroidism

Moyes Veronica , Alexandraki Krystallenia , Monson John , Akker Scott , Chew Shern

Cinacalcet is a calcimimetic agent licensed for the treatment of secondary hyperparathyroidism and parathyroid carcinoma. Multiple endocrine neoplasia type 1 (MEN1) patients may benefit considerably from cinacalcet. Affected patients have hyperplasia of multiple parathyroid glands, rather than a single resectable adenoma. Surgical cure requires removal of all parathyroid tissue, which is often unsuccessful, resulting in multiple neck explorations and hypoparathyroidism. Cinaca...

ea00100p52 | Poster Presentations | SFEEU2024

Normalisation of parathyroid hormone in a patient with pseudohypoparathyroidism type 1b following a diagnosis of lymphoma

Anandhakrishnan Ananthi , Monson John P , Gaoatswe Gadintshware , Gunganah Kirun

Clinical case: A 23-year-old woman with genetically confirmed pseudohypoparathyroidism type 1b (PHP1b) reported a one-month history of progressive bilateral cervical lymphadenopathy at her most recent outpatient visit. This was associated with night sweats and a dry cough, but no weight loss, haemoptysis or recent foreign travel. Clinical examination revealed widespread non-tender cervical and inguinal lymphadenopathy with no hepatosplenomegaly. An expedited ultrasound guided ...

ea0091oc7 | Oral Communications | SFEEU2023

Hypokalaemia: An unusual feature of pseudohypoprathyroidism Type 1b

Anandhakrishnan* Ananthi , Flynn* Rachel , Khan Jansher , Dodzo Kumbirai , Gaoatswe Gadintshware , Monson John P , Gunganah Kirun

Section 1: Case history: A 23-year-old female presented to the Emergency Department with a 3-month history of intermittent chest pain and palpitations. She was found to be hypokalaemic and hypocalcaemic. On direct-questioning she reported 3 weeks of perioral paraesthesia and muscle spasms. She had an unrestricted diet and no other personal or family history of note. She was normotensive with a sinus tachycardia and normal QT-interval, Chvostek’s negative, with no features...

ea0015p91 | Clinical practice/governance and case reports | SFEBES2008

Growth hormone replacement in patients with treated germ cell tumours: safety issues

Chung Teng-Teng LL , Kelly Phillip , Metcalfe Karl , Akker Scott , Drake William , Monson John

The potential for primary tumour relapse is an important consideration during GH replacement therapy (GHR). We report 3 cases of relapse of intra cranial germ cell tumour (GCT) during GHR.Patient 1: An 11 year-old female presenting with visual loss and short stature due to a suprasellar malignant teratoma. She was successfully treated with bleomycin, etoposide and cisplatinum (BEP) and intrathecal chemotherapy. She suffered a first relapse two years late...

ea0015p263 | Pituitary | SFEBES2008

Endoscopic transphenoidal pituitary surgery: results in 21 consecutive patients with Cushing’s disease

Hanson Philippa , Akker Scott , Monson John , Alusi Gus , Sabin Ian , Drake Will

Introduction: We present the outcome for the first 21 patients undergoing neuronavigation–guided, endoscopic transphenoidal surgery for pituitary dependent Cushing’s disease in our centre since August 2001. All operations were consecutive, and undertaken by the same neurosurgeon and endoscopic nasal surgeon.Methods: Records are available for 20 cases. Pre and post operative management of cases was led by the endocrine team with standard assessm...

ea00100oc10 | Oral Communications | SFEEU2024

Autoimmune hypothalamitis and hypophysitis due to SLE manifesting as arginine vasopressin deficiency and hypothalamic hyperphagia

Anandhakrishnan Ananthi , Akker Scott , Keddie Stephen , Monson John P , Gunganah Kirun

Clinical Case: A 30-year-old female was referred with subfertility and hypogonadotropic hypogonadism. She had systemic lupus erythematosus (SLE) and was on maintenance 5 mg prednisolone, having received intermittent high doses since her diagnosis in 2018. She reported 12 months of amenorrhea and reduced libido without galactorrhoea, despite regular menses since menarche aged13. This coincided with a rapid weight gain of 20 kg. On examination, her BMI was 36.8 kg/m2,...

ea0037gp.04.07 | Steroids | ECE2015

Differential regulation of 11β-hydroxysteroid dehydrogenase type 1 activity in patients with differing aetiologies of hypopituitarism

Behan Lucy Ann , Rogers Bairbre , Maher K , Taylor Norman F , Smith Diarmuid , Thompson Chris J , Monson John P , Agha Amar

Pituitary patients with different aetiologies of hypopituitarism exhibit differing phenotypes despite optimal replacement therapy. We hypothesised that differential regulation of the isoenzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which mediates the autocrine conversion of cortisone to cortisol in adipose tissues and liver may play a role.We prospectively studied 11β-HSD1 activity through analysis of 24 h urine cortisol/cortisone ...

ea0030p2 | (1) | BSPED2012

Outcome of endoscopic transsphenoidal pituitary surgery in four paediatric Cushing's disease patients: a new therapeutic approach

Storr Helen L , Drake William M , Akker Scott A , Monson John P , Savage Martin O , Alusi Ghassan , Sabin H Ian

Selective transsphenoidal adenomectomy remains the accepted first line treatment for Cushing’s disease (CD), until recently by microscopic (sublabial) transsphenoidal pituitary surgery. Endonasal transsphenoidal endoscopic surgery is emerging as a novel, less invasive treatment for pituitary adenomas with lower postoperative complications and morbidity. The safety of endoscopic surgery has been extensively reviewed in adult patients and is now considered best practice for...