ea0009s33 | Symposium 8: Hyperinsulinism–induced hypoglycaemia | BES2005
Camacho-Hubner C
, Miraki-Moud F
, Montes B
, Tweed K
, Besser M
, Monson J
, Grossman A
Non-islet cell tumour hypoglycaemia (NICTH) is a syndrome associated with overproduction of pro-IGF-II, a 14-18 kDa product of incomplete proteolytic cleavage of IGF-II pro-hormone, usually secreted by large mesenchymal tumours. The excess of pro-IGF-II in NICTH leads to a reduction in circulating insulin, GH, IGF-I, IGFBP-3 and acid-labile subunit (ALS) levels and to an increase in IGF binding protein-2 (IGFBP-2). IGFs and IGFBP-3 are found primarily in binary complexes of ap...