Searchable abstracts of presentations at key conferences in endocrinology

ea0051p039 | Pituitary and growth | BSPED2017

Can the TSH index be used as a predictor of central hypothyroidism in children?

Monti Elena , Stroek Kevin , Morandi Grazia , Improda Nicola , Rapti Elena , Mattone Maria Celeste , Dattani Mehul

Introduction: Central hypothyroidism (CeH) is diagnosed when low thyrotropin (TSH) is associated with a free thyroxine (fT4) below the normal range. Jostel proposed a ’fT4-adjusted TSH’ (TSH index: TSHI = log TSH +0.1345 · fT4.), to estimate the degree of pituitary dysfunction (Jostel et al. Clin End 2009).Methods: Retrospective analysis of patients investigated for pituitary hormone deficiencies (n=276; M:F 166:...

ea0058oc8.3 | Oral Communications 8 | BSPED2018

Attitudes toward fertility and reproductive health among transgender adolescents

Walton-Betancourth Sandra , Monti Elena , Adu-Gyamfi Kirpal , Roberts Alice , Clarkson Kerry , Ward Stephanie , Butler Gary

Introduction: Utilization rates of fertility preservation among transgender adolescents (TA) are low. Few studies have addressed the reproductive desires of this population. The aim of this study was to assess TA parenthood goals, attitudes about fertility preservation (FP) and perceived barriers to successful gamete banking.Methods: Transgender adolescents who attended the Gender Identity Development Service (GIDS - endocrine clinic) between March and J...

ea0058p019 | Gonadal | BSPED2018

Adolescents with HH: what outcome do they want from the gonadotropin stimulation process?

Monti Elena , Roberts Alice , Kleczewski Sara , Walton-Betancourth Sandra , Butler Gary

Background: Male adolescents with hypogonadotropic hypogonadism (HH) or delayed puberty start pubertal induction from 12–14 years. Testosterone obtains secondarysexual characteristics and improves psychosocial well being. Gonadotropin releasing hormone (GnRH) or recombinant FSH (rFSH) and human chorionic gonadotropin (hCG) generate testicular growth (fertility) and testicular testosterone production. HCG-rFSH treatment increase testis size and improves the quality of life...

ea0058p030 | Miscellaneous Endocrinology | BSPED2018

Fertility preservation for transgender adolescents: The parent’s view

Walton-Betancourth Sandra , Monti Elena , Adu-Gyamfi Kirpal , Roberts Alice , Clarkson Kerry , Ward Stephanie , Butler Gary

Background: Fertility preservation (FP) amongst transgender adolescents (TA) is receiving more attention as individuals are transitioning at younger ages. Parents have a key role at exploring options for their children and are usually the ones responsible for consenting to interventions. Our aim was to explore parent’s attitudes regarding their offspring parenthood goals, FP counselling and perceived barriers to successful gamete banking.Methods: Pa...

ea0058p028 | Miscellaneous Endocrinology | BSPED2018

A 10 year experience of the management of severe hypocalcaemia associated with thymus transplantation in a United Kingdom tertiary centre

Goff Nicole , Katugampola Harshini , Monti Elena , Taylor Katherine , Amin Rakesh , Hindmarsh Peter , Peters Catherine , Shah Pratik , Spoudeas Helen , Dattani Mehul , Allgrove Jeremy , Brain Caroline

Background: Thymus transplantation is undertaken for conditions associated with severe immunodeficiency. These comprise various genetic and syndromic associations including 22q deletion syndrome, CHARGE association, diabetic embryopathy, and other rarer conditions. Some of these conditions are associated with hypoparathyroidism and therefore hypocalcaemia. There are no established guidelines on the management and prevention of hypocalcaemia during the transplant period.<p ...

ea0045p45 | Gonadal, DSD and reproduction | BSPED2016

5-alpha reductase deficiency: insights into the diagnosis and management of a rare condition

Monti Elena , Man Elim , Torpiano John , Rumsby Gill , Carmichael Polly , Storr Helen , Brain Caroline , Buchanan Charles , Conway Gerard , Spoudeas Helen , Mushtaq Imran , Hussain Khalid , Hughes Ieuan , Greening James , Achermann John , Dattani Mehul

Introduction: 5-alpha reductase deficiency (5aRD) is a rare cause of 46XY DSD, that affects sex development before birth and during puberty. The incidence is unknown; affected individuals have been described from all around the world, particularly in small communities or where consanguinity is common.Methods: A 20-year retrospective review of presenting features, biochemical data and genetic analysis of all patients presenting to a single multidisciplina...