Searchable abstracts of presentations at key conferences in endocrinology

ea0016p322 | Endocrine tumours | ECE2008

Effect of Ginkgo biloba extract supplementation on genotoxic damage after thyroid remnant ablation by 131I

Dardano Angela , Ballardin Michela , Traino Claudio , Caraccio Nadia , Colato Chiara , Barale Roberto , Mariani Giuliano , Ferdeghini Marco , Monzani Fabio

Background: Radioiodine (131I) therapy is performed in patients with differentiated thyroid cancer (DTC), either for thyroid remnant ablation or treating distant metastasis. Although 131I therapy is generally considered safe, a genotoxic damage has been demonstrated both in vivo and in vitro.Aim: To evaluate the possible effect of Ginkgo biloba extract (EGb 761) supplementation on the time-course (up to 1...

ea0014p129 | (1) | ECE2007

A loss-of-function polymorphic mutation in the P2X7 receptor gene in patients with papillary thyroid cancer

Dardano Angela , Falzoni Simonetta , Polini Antonio , Bemi Alessia , Solini Anna , Caraccio Nadia , Di Virgilio Francesco , Monzani Fabio

Extracellular nucleotides, via specific plasma membrane receptors (P2Rs) of the X and Y subtype, modulate several cell functions, including cell-to-cell cross talk. We have previously demonstrated the expression of several functional P2XRs subtypes, including P2X7, in primary human thyrocytes. P2X7 is the main player in inflammation and immunomodulation; a strong expression of this receptor has been shown in several human solid tumors. Polymorphisms of the gene enco...

ea0073aep802 | Late Breaking | ECE2021

Hypovitaminosis D in patients with SARS-CoV2: Correlation with inflammatory markers and severity of the disease

Saponaro Federica , Franzini Maria , Okoye Chukwuma , Antognoli Rachele , Monzani Fabio , Celi Alessandro , Zucchi Riccardo , Paolicchi Aldo , Saba Alessandro

In March 2020, the infection due to COVID-19 spread as a pandemic emergence showing a mutable phenotype ranging from asymptomatic to lethal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Among multiple biological and environmental investigated factors, vitamin D status was proposed as a credible candidate, since hypovitaminosis D could be identified as a modifiable risk factor and a potential tool in SARS-CoV-2 ...

ea0014p130 | (1) | ECE2007

Enhanced expression of functional P2X7 receptor in human papillary thyroid cancer

Dardano Angela , Ferrari Davide , Cuccato Sabina , Santini Eleonora , Caraccio Nadia , Gulinelli Sara , Callegari Giulia , Faviana Pinuccia , Solini Anna , Di Virgilio Francesco , Monzani Fabio

Extracellular ATP modulates several biological processes via activation of plasma membrane receptors (P2Rs) in normal human thyrocytes (NT). We characterized P2Rs expression and function in two thyroid cancer cell lines: FB1 (anaplastic cancer) and FB2 [papillary cancer (PTC)]. P2Rs expression was evaluated by RT-PCR and WB, intracellular Ca2+changes by fluorimetric technique (Fura2-AM), IL-6 release by ELISA, intracellular [i(ATP)] and extracellular ATP [...