Searchable abstracts of presentations at key conferences in endocrinology

ea0078nep2.1 | Session 2 | BSPED2021

Interpretation of abnormal thyroid function tests in children and adolescents

Moran Carla

Thyroid dysfunction is common, and thyroid function tests (TFTs) are amongst the most frequently requested laboratory measurements, both in the adult and paediatric setting. Fortunately, most TFTs are straightforward to interpret and confirm a clinical diagnosis of eu-, hypo- or hyperthyroidism. In most cases, the underlying cause of thyroid dysfunction is readily apparent from clinical findings and standard investigations (e.g. antibody testing, radionuclide scan). In a subse...

ea0081pl6 | Thyroid Hormone Resistance, Diagnosis and Treatment | ECE2022

Thyroid hormone resistance, diagnosis and treatment

Moran Carla

Resistance to Thyroid hormone (RTH) encompasses various disorders of Thyroid Hormone (TH) Action, including defective signalling through TH Receptors (RTH alpha, RTH Beta), abnormal TH metabolism (Selenoprotein deficiency) and altered cellular entry of TH (MCT8 defects). In this talk, I will focus on RTH alpha and beta. RTH beta is usually associated with mutations in the THRB gene and is often readily identified, due to the associated typical biochemical pattern of r...

ea0059cmw2.3 | Workshop 2: Endocrine emergencies | SFEBES2018

Thyrotoxic crises

Moran Carla

Thyroid storm is a rare medical emergency with high mortality and is difficult to diagnose and treat. The optimal treatment regimen is not clear, and options include combinations of beta blockade, high dose anti-thyroid drugs, potassium iodide, dexamethasone, iodinated contrast agents, plasmapheresis and dialysis. Patients with severe, uncontrolled thyrotoxicosis, unresponsive to anti-thyroid drug therapy, represent a group of patients in whom treatment can be particularly cha...

ea0038cmw3.2 | Workshop 3: Biological therapies - cause and cure of endocrine diseases | SFEBES2015

Endocrine sequelae of biological therapies (Campath, other MABs, etc.)

Moran Carla

Biological therapies include interleukins, interferons, and MABs. Over the past few years, the use of MAB to treat cancer and other diseases such as multiple sclerosis (MS) have increased; some of these frequently cause endocrine side effects.Alemtuzumab, a MAB directed at CD52 on T and B lymphocytes, is very effective in reducing relapse rates and improving disability in relapsing remitting MS, however is frequently (16–35%) associated with the ons...

ea0050p013 | Adrenal and Steroids | SFEBES2017

Short synacthen test requests may be reduced by considering test indication and identifying a 9am cortisol value that predicts test result

Wong Christine , Moran Carla

Background: Short synacthen tests (SSTs) are routinely performed for the investigation of adrenal insufficiency (AI), but are costly and time consuming. The frequency of SST testing could be reduced by prioritising testing for specific indications (based on likelihood of failure of the test), and also by identification of an assay-specific 9am cortisol level that obviates the need to proceed to SST.Methods: Retrospective review...

ea0050p013 | Adrenal and Steroids | SFEBES2017

Short synacthen test requests may be reduced by considering test indication and identifying a 9am cortisol value that predicts test result

Wong Christine , Moran Carla

Background: Short synacthen tests (SSTs) are routinely performed for the investigation of adrenal insufficiency (AI), but are costly and time consuming. The frequency of SST testing could be reduced by prioritising testing for specific indications (based on likelihood of failure of the test), and also by identification of an assay-specific 9am cortisol level that obviates the need to proceed to SST.Methods: Retrospective review...

ea0082wc4 | Workshop C: Disorders of the thyroid gland | SFEEU2022

A grave interference: TSH interference due to macro-TSH post-thyroidectomy for graves” disease

McCarthy Aisling , Moran Carla

A 26 year old gentleman presented to his GP in July 2018 with a one month history of thyrotoxic symptoms, including palpitations and weight loss. His initial thyroid function tests (TFTs) showed a hyperthyroid picture, including a FT4 of >100pmol/l (RR 12-22). His TSH receptor antibody was 11.1 IU/l (RR <1.75). He had no evidence of thyroid eye disease, and no goitre or thyroid nodules on exam. His Graves” disease was initially managed medically with carbimazole. ...

ea0041mte2.1-mte2.2 | (1) | ECE2016

Difficult thyroid cases

Moran Carla , Persani Luca

In clinical practice, most thyroid disease is due to thyroid gland dysfunction and so can be detected by measurement of TSH alone. This is because the negative feedback of thyroid hormones on the hypothalamus and pituitary gland result in TSH levels that are closely, and inversely, correlated with circulating free thyroid hormone (FT4, FT3) levels. However, several conditions are exceptions to this rule and can be very hard to diagnose also due to a certa...

ea0077p205 | Metabolism, Obesity and Diabetes | SFEBES2021

Assessing and Improving junior doctors’ knowledge and confidence in managing Diabetes Mellitus in the end-of-life setting

Tansey David J. , Tiernan Eoin , Moran Carla

An anonymised online survey was created to evaluate junior doctor’s competency and confidence with decision-making scenarios in managing patients with diabetes at the end-of-life. 26 doctors working at the Beacon Hospital completed the online survey. A structured education programme was then delivered to the junior doctors where the critical information pertaining to the management of diabetes at the end-of-life was discussed, based on the ABCD 2011 and Diabetes UK 2013 a...

ea0050p395 | Thyroid | SFEBES2017

Recent liothyronine price increases have changed primary care prescription practice, with increased referrals to specialist care

Terry Isabelle , Perros Petros , Moran Carla

Background: The cost of liothyronine (T3) has significantly increased, possibly affecting prescription practices.Methods: An online questionnaire was designed to assess current T3 use by UK endocrinologists and to determine whether the price increase resulted in a change in primary care prescription practices. Consultant grade members of the Society for Endocrinology Thyroid Network were invited to partake.Results: Re...