Searchable abstracts of presentations at key conferences in endocrinology

ea0025p246 | Pituitary | SFEBES2011

SIADH of cancer: rapid diagnostic evaluation using copeptin as a marker of AVP

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

With the advent of vaptans as a therapeutic option, rapid and precise diagnosis of SIADH is essential. SIADH due to paraneoplastic stimulation of AVP is an expected but not the only cause of hyponatraemia in cancer patients. Therefore a precise evaluation of the cause of hyponatraemia is necessary before any therapeutic approach. Using Copeptin, a stable marker of AVP, which is stoichiometrically released with AVP, we evaluated 49 patients with hyponatremia due to various form...

ea0022oc3.2 | Pituitary | ECE2010

Copeptin, an arginine vasopressin (AVP) marker, as a diagnostic aid in SIADH of cancer

Dixit Kashinath , Morgenthaler Nils , Brabant Georg

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested in various pathophysiological conditions including myocardial infarction and stroke. Paraneoplastic stimulation of AVP/copeptin is expected in patients with cancer leading to hyponatraemia due to SIADH.Here, we evaluated copeptin levels in 50 patients with hyponatraemia du...

ea0021p292 | Pituitary | SFEBES2009

Circadian and pulsatile secretion of copeptin, an arginine vasopressin (AVP) marker, argues against a physiological role of AVP in cortisol release

Darzy Ken , Dixit Kashinath , Shalet Stephen , Morgenthaler Nils , Brabant Georg

Copeptin is a stable AVP marker and stoichiometrically released with AVP. It closely reflects changes in water balance. Its stimulation in severe stress has recently has been suggested for the early diagnosis of myocardial infarction but clear definition of the physiological variability is necessary. Here, we studied the pulsatile and circadian variation in healthy individuals and compared copeptin to cortisol rhythms.Copeptin levels were sampled every 2...

ea0020oc3.6 | Reproduction/Stress/Endocrine Disruptors | ECE2009

Cortisol as a prognostic marker of outcome in acute ischemic cerebrovascular events

Neidert Stefanie , Katan Mira , Fluri Felix , Morgenthaler Nils , Schuetz Philipp , Mueller Beat , Christ-Crain Mirjam

Background: Stroke is the second commonest reason of mortality worldwide and a major cause of long term disability. Early prediction of outcome is important for allocation of therapeutic strategies. Endocrine alterations of the hypothalamus┬ľpituitary┬ľaxis (HPA) are one of the first stress-induced alterations after cerebral ischemia. We evaluated the prognostic value of cortisol for outcome in acute ischemic cerebrovascular events.Method: In an ...

ea0016p159 | Clinical cases | ECE2008

How the workup of low renin hypertension lead to the diagnosis of SIADH

Kolentini Chara , Morgenthaler Nils , Mertes Gerhard , Cupisti Angela , Schott Matthias , Scherbaum Werner A , Willenberg Holger S

A patient was referred to us because he had hypokalemic hypertension and no detectable blood concentrations of renin and aldosterone. In addition, this patient had an adrenal mass. Since he was hyponatremic, he was put on fludrocortisone.At presentation, we found that the patient was normonatremic and hypokalemic and had a high sodium to urinary sodium to potassium to urinary potassium (SUSPUP) ratio. But review of older laboratory results showed an inad...

ea0016p504 | Obesity | ECE2008

Plasma adrenomedullin positively correlates to body mass index, and significantly decreases after bariatric surgery

Clodi Martin , Vila Greisa , Riedl Michaela , Handisurya Ammon , Maier Christina , Morgenthaler Nils G , Luger Anton

Adrenomedullin is a vasoactive peptide originally discovered in extracts of human pheochromocytoma. It is highly expressed in plasma and adipose tissue of obese subjects and considered as a member of the adipokine family. Adrenomedullin inhibits adipogenesis under the transcriptional control of insulin. We determined plasma adrenomedullin concentrations in a cohort of 360 healthy subjects and found a very significant positive correlation to body mass index (BMI). In parallel, ...

ea0013p230 | Neuroendocrinology and behaviour (including pituitary) | SFEBES2007

The AVP precursor, Copeptin, predicts the severity of acute and prolonged traumatic brain injury (TBI)

Kleindienst Andrea , Weigel Daniel , Morgenthaler Nils , Struck Joachim , Buchfelder Michael , Brabant Georg

Introduction: The incidence of water and electrolyte disturbances following traumatic brain injury (TBI) is considerable and has been attributed to a dysregulation of the hypothalamic peptide arginine-vasopressin (AVP). Copeptin, the C-terminal part of the AVP prohormone, is stoichiometrically secreted together with mature AVP. Due to his long ex vivo stability, the AVP precursor, copeptin, can be used as a surrogate of AVP readily to be measured in serum or plasma. In ...