Searchable abstracts of presentations at key conferences in endocrinology

ea0023p31 | (1) | BSPED2009

Prophylactic Thyroidectomy in Children with Multiple Endocrine Neoplasia Type 2

Morkane Clare , Raptis Dimitri , Brain Caroline , Spoudeas Helen , Dattani Mehul , Hindmarsch Peter , Piero Agostino , DeCoppi Paolo , Kurzawinski Tom

Background: The most common cause of death in patients with Multiple Endocrine Neoplasia type 2 is medullary thyroid carcinoma. All patients with MEN2 develop this cancer and Prophylactic Thyroidectomy (PT) is recommended to prevent malignant transformation.Method: This study reviews our experience of treating children identified as carriers of a RET mutation diagnostic of MEN-2A. Data was collected by reviewing patient notes and hospital electronic data...

ea0027p28 | (1) | BSPED2011

Prophylactic thyroidectomy in children with MEN2 in the United Kingdom

Prete Francesco Paolo , Morkane Clare , Watkinson J , Shaw N , Alvi S , Squire R , Harrison B , Wales J , Clayton P , Morrison P , Carson D , Brain C , Hindmarsh P , Dattani M , Spoudeas H , Buchanan C , Albanese A , Amin R , Piero A , Kurzawinski T

Introduction: Timing, extent, complications rate and long term results of paediatric prophylactic thyroidectomy (pPT) for MEN2 in the UK are unknown.Methods: All UK centers performing pPT were invited to participate in the study.Data were obtained from notes and hospitals electronic databases.Results: Fifty-one children (27 males) were included.All had genetic test at the mean age of 5 years (median 3, range 0.25–15), confirmi...