Endocrine Abstracts

Introduction: Hereditary hemochromatosis is a common disorder in white population with a prevalence of 4-6.4%. It is a systemic disorder that affects multiple organs. It could affect the pituitary gland leading to hypogonadotropic hypogonadism and could affect other pituitary hormones to a lesser extent. We present a rare case of hereditary hemochromatosis leading to hypotension most likely due to iron infiltration of the pituitary gland.Case presentatio...

Introduction: The mean time from onset of symptoms to diagnosis in NEN is around 5-7 years. Late stage NEN is often diagnosed during an emergency admission. The difference in overall survival (OS) between emergency and elective diagnoses has not been studied. This study assesses factors associated with emergency presentation (EP) versus routine presentation (RP), evaluates factors associated with late presentation, and correlates these with OS. Methods: ...

Introduction: TNM 8 is the staging system for GEP-NEN, guiding prognosis and treatment. However, it ignores important prognostic factors including age, sex, race, tumour site, and morphology. Methods: 35,347 adults diagnosed between 2011-2021 with GEP-NEN and had no missing data in any variables were extracted from SEER. Age, sex, race, tumour site, size, morphology, number of lymph nodes and metastasis site were used to create 3 clusters using K-means M...

Introduction: European Neuroendocrine Tumour Society guidelines advocate the use of platinum-based chemotherapy in combination with Etoposide as first line chemotherapy in advanced GEP-NEC. Following this regime, 30% of digestive NEC and 60% of colorectal NEC showed a lack of benefit or evidence of disease progression. Available retrospective evidence is from small studies. Other studies have shown BMI relates to survival in NEN. This study aims at studying chemotherapy regime...