Searchable abstracts of presentations at key conferences in endocrinology

ea0020p514 | Endocrine Disruptors | ECE2009

Association of CTLA4+49 A/G polymorphism with type 1 diabetes in Tunisian population

Jihen Benmansour , Mouna Stayoussef , Wassim Almawi , Touhami Mahjoub

Type 1 diabetes (T1D) is a complex autoimmune disease. Several genetic loci have been implicated in the susceptibility to this illness. Evaluated was the role of the CTLA4 exon 1 A49G polymorphism and its role as a risk factor for T1D in our population. DNA from 120 patients with T1D and 96 control individuals were genotyped for CTLA4 exon 1 polymorphism by polymerase chain reaction (PCR) amplification-restriction enzyme analysis and PCR amplification that used sequence-specif...