Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1165 | Nuclear receptors and Signal transduction | ICEECE2012

LPS administration modulates hypothalamic AMPK and glucose homeostasis in mice

Santos G. , Vitorino D. , Moura R. , Roman E. , Velloso L. , Torsoni A. , Torsoni M.

Introduction: Hypothalamic AMP-activated protein kinase (AMPK) has emerged as a key molecular player in energy homeostasis. It participates of glucose homeostasis modulating liver glucose production. It is known that endotoxin shock presents various complicated metabolic aspects. Among them, in later phase circulatory collapse and hypoglycemia are induced with a deterioration of energy metabolism. Here we evaluated the participation of hypothalamic AMPK in the modulation of he...

ea0029p1328 | Paediatric endocrinology | ICEECE2012

Short stature due to late-onset congenital adrenal hyperplasia

Rodrigues P. , Souto S. , Costa S. , Moura R. , Alves D. , Freitas P. , Correia C. , Costa C. , Fontoura M.

Introduction: Precocious pubarche is defined as pubic hair onset before age eight in girls and age nine in boys. In 5–20% of cases the cause is late-onset congenital adrenal hyperplasia (LO-CAH), which is due mainly to non-classic 21-hydroxylase deficiency. If not promptly diagnosed, it can lead to accelerated bone maturation, short final height, and in adulthood to severe acne, hirsutism and infertility.Case report: Adolescent male, 15 years-old, h...