Endocrine Abstracts

Background: Thyroid cancer incidence is increasing, especially the cancers ≤1 cm (T1a). Previous evidence suggests underuse of FNA. Several international guidelines for the management of thyroid cancer have been published. Especially the year 2006 was a hallmark, with the publication of both the ETA consensus and ATA guidelines.Aim: Compare thyroid cancer subtypes and management before and after 2006.Methodology: Retrospectiv...

Objective: Nation-wide reimbursement of intermittently scanned continuous glucose monitoring (isCGM) for people with type 1 diabetes was introduced in Belgium in 2016. We investigated whether diabetes knowledge and health literacy would impact glycemic control after one year of isCGM use.Research design and methods: In this substudy of the FUTURE trial, a prospective observational real-world cohort study in individuals with type 1 diabetes ≥16 year...

Introduction: Several studies identified pre-treatment parameters that could help in the prediction of the thyroid functional outcome after radioactive iodine therapy (RAI) in Graves’ disease. However, the role of the thyroid peroxidase antibody (TPO Ab) status is not well studied.Objectives: We investigated if a positive TPO Ab status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for de...

Objective: We investigated if a positive thyroid peroxidase antibody (TPO Ab) status before radioactive iodine (RAI) therapy in patients with Graves’ hyperthyroidism is a predictive factor for developing hypothyroidism after RAI.Methods: We performed a retrospective study of patients with Graves’ hyperthyroidism with known TPO Ab status, receiving a first administration of RAI. Patients from 4 thyroid outpatient centres in Belgium receiving a f...

Aims: To determine predictors of neonatal adiposity and differences in associations by fetal sex in women with gestational diabetes mellitus (GDM), normal-weight and overweight (BMI ≥ 25 kg/m²) normal glucose tolerant women (NGT).Methods: Skinfold thickness was measured in 576 newborns, and cord blood leptin, c-peptide and lipids in 327 newborns in a multi-centric prospective cohort study.Results: Compared to ...

Aims: To determine the fasting plasma glucose (FPG) level at which an oral glucose tolerance test (OGTT) could be avoided to screen for gestational diabetes (GDM) and to evaluate the characteristics of women across this FPG threshold.Methods: A multi-centric prospective cohort study (BEDIP-N) with 1843 women receiving screening for GDM with a 75g OGTT.Results: A FPG < 78 mg/dl was the FPG cut-off with the best trade-off to limi...

Aims: To compare the characteristics, pregnancy outcomes and tolerance of screening tests between women who prefer a two-step screening strategy with a glucose challenge test (GCT), women who prefer an one-step screening strategy with an oral glucose tolerance test (OGTT) and women without clear preference for screening method for gestational diabetes mellitus (GDM). Methods: 1803 women from a Belgian multi-centric prospective cohort study (BEDIP-N study...

Aim: To determine the association between thyroid function and the risk for gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.Methods: This case-control study was a sub-analysis of the BEDIP-N study, in which 199 GDM women were matched for age and body mass index with 398 controls. Thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and thyroid peroxidase (TPO) antibodies were measured at 6-14 weeks and ...

Aims: To determine the impact of antenatal depression on pregnancy outcomes in women with gestational diabetes mellitus (GDM) and women with normal glucose tolerance (NGT).Methods: 1843 women from a Belgian multi-centric prospective cohort study (BEDIP-N Study) received universal screening for GDM with a 75 g OGTT and the IADPSG criteria. The Center for Epidemiologic Studies – Depression (CES-D) questionnaire was completed at the time of the OGTT (b...