Searchable abstracts of presentations at key conferences in endocrinology

ea0005p131 | Endocrine Tumours and Neoplasia | BES2003

The presence of ghrelin protein in the rat hypothalamus and the effect of ghrelin on corticotrophin releasing hormone (CRH) and arginine vasopressin (AVP) release from rat hypothalamic explants pituitary tumours

Mozid A , Tringali G , Forsling M , Hendricks M , Ajodha S , Edwards R , Navarra P , Grossman A , Korbonits M

Ghrelin is a brain-gut peptide originally identified in the stomach. It binds to and stimulates the growth hormone secretagogue receptor type 1a (GHS-R). The presence of ghrelin in hypothalamic tissue was studied. It has been previously established that neither the synthetic GHSs, nor the endogenous hormone ghrelin, is specific for GH stimulation: they generally also stimulate the HPA axis as well as prolactin release. Since there is no direct stimulatory effect on ACTH releas...

ea0004oc11 | Endocrine tumours and neoplasia | SFE2002

Ghrelin Exerts a Proliferative Effect on a Rat Pituitary Somatotroph Cell Line

Mozid A , Fowkes R , Morris D , Sidhu K , Khalaf S , Burrin J , Grossman A , Korbonits M

BACKGROUND: Ghrelin is a novel 28-amino acid peptide which was isolated from the rat stomach and has now been shown to have a widespread tissue distribution. Ghrelin is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a), and stimulates growth hormone (GH) release via the hypothalamus as well as by a direct action on the pituitary GHS-R1a. Ghrelin and the GHS-R1a also coexist within the pituitary. There are conflicting data regarding the effects...