Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1335 | Pituitary Basic | ICEECE2012

Multiple enhancers regulate expression of the human LHX3 gene in the developing pituitary

Park S. , Mullen R. , Rhodes S.

LHX3 is a LIM homeodomain transcription factor necessary for proper development of the pituitary and central nervous system. Patients with mutations in coding regions of the LHX3 gene have complex syndromes including combined pituitary hormone deficiency and nervous system defects resulting in symptoms such as dwarfism, thyroid insufficiency, infertility, and developmental delay. Although previous studies from our group and others have identified promoter and intronic elements...