Endocrine Abstracts

Agranulocytosis complicating carbimazole (CBZ) therapy occurs in <1% of treated patients and generally presents in a charachteristic way. A 72 year old female presented with thyrotoxicosis (FT4 44.9 pmol/l, NR 12.5-20.5), confirmed as Graves disease on investigation. Treatment was commenced with carbimazole. 4 weeks after beginning therapy she complained of a painful red eye, nausea, anorexia and weight loss. Examination confirmed iritis. Subsequent investigations revealed ...