Searchable abstracts of presentations at key conferences in endocrinology

ea0081p200 | Thyroid | ECE2022

Thyroid dysfunction related to SARS-CoV-2 vaccination: the experience of a single center in Milan

Muller Ilaria , Di Marco Francesco , Arosio Maura , Salvi Mario

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) has caused millions of deaths worldwide, thus a massive SARS-CoV-2 vaccination campaign has been launched since the end of 2020. Viruses and vaccines can induce adverse thyroid effects; SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT) and Graves’ disease (GD). We aimed to study the occurrence o...

ea0014p399 | (1) | ECE2007

Prevalence of primary hyperparatiroidism in treated and untreated breast cancer

Giani Claudio , Fiore Emilio , Giustarini Elisa , Muller Ilaria , Vignali Edda , Fierabracci Paola , Pinchera Aldo

Hypercalcemia is a frequent metabolic disorder in metastatic breast cancer (BC). Aim of this study was to evaluate the incidence of hypercalcemia due to PHPT in BC patients. The study group included 271 consecutive BC, mean age±S.D. 57.7±11.96 yrs. 100/271(36.9%) evaluated at different times after mastectomy (A) and 171(63.1%) before surgery (B), with no distant metastases. Age matched control group included 108 healthy women (Co) and 70 women with thy...

ea0084ps1-01-08 | COVID & Thyroid Disease | ETA2022

Graves’ orbitopathy and subacute thyroiditis related to SARS-CoV-2 infection or vaccination: the experience of a single centre in milan, italy

Muller Ilaria , Crivicich Erica , Di Marco Francesco , Curro Nicola , Arosio Maura , Salvi Mario

Background: The Covid-19 pandemic caused by the severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) determined millions of deaths worldwide, thus at the end of 2020 a massive vaccination campaign has been launched. SARS-CoV-2 infection and vaccines have been associated with several thyroid disorders, especially subacute thyroiditis (SAT), Graves’ disease (GD) and orbitopathy (GO). We studied the occurrence of SAT and GO following SARS-CoV-2 infection or vaccinati...

ea0084ps3-12-112 | Graves’ Disease 2 and Orbitopathy | ETA2022

Alemtuzumab-induced graves’ orbitopathy successfully treated with a single dose of rituximab

Di Marco Francesco , Porcaro Laura , Crivicich Erica , Curro Nicola , Arosio Maura , Muller Ilaria , Salvi Mario

Introduction: The humanized antibody anti-CD52+ alemtuzumab has been approved since 2014 for the treatment of relapsing-remitting multiple sclerosis (RRMS). Immune reconstitution after alemtuzumab induces thyroid autoimmunity in 34-41% of patients with RRMS, with Graves’ disease (GD) accounting for 63-65% of cases. Graves’ Orbitopathy (GO) may also occur in 13% of patients after alemtuzumab and is scarcely reported. Here we present the first case of alemtuzumab-induc...

ea0044p245 | Thyroid | SFEBES2016

Thyroid autoimmunity as a biomarker of breast cancer outcome: large-scale study using data from the Taxotere as Adjuvant Chemotherapy Trial (TACT: CRUK01/001)

Muller Ilaria , Kilburn Lucy , Taylor Peter , Barrett-Lee Peter , Bliss Judith , Paul Ellis , Marian Ludgate , Dayan Colin

Background: An association between breast cancer (BC) and thyroid autoimmunity has been frequently observed, and several small-scale studies correlated the presence of autoantibodies to thyroid peroxidase (TPOAb) with an improved BC outcome. We aimed to clarify in a large cohort of patients whether circulating TPOAb are prognostic for BC recurrence.Materials and methods: Available plasma samples for patients with node-positive or high-risk node-negative ...

ea0037gp.26.03 | Thyroid – hypothyroidism | ECE2015

Adverse metabolic correlations relate to free T3 levels in subclinical hypothyroidism; common FOXE1 polymorphisms associate with blood pressure

de Lloyd Anna , Muller Ilaria , Dodd Alan , Bakhsh Ameen , Durrant Hilary , Zhang Lei , Evans Carol , Rees Aled , Ludgate Marian

Introduction: The effects of mild subclinical hypothyroidism (SH; TSH <10 mU/l) on metabolic outcomes are unclear. This may relate to differences in aetiology, including thyroid autoimmunity or genetic factors such as TSH-receptor mutations (TSHR-M) and FOXE1 polyalanine tract length (FOXE1–PTL) polymorphisms, which are associated with altered thyroid function. We hypothesised that the metabolic manifestations of SH may depend upon its aetiology.<p class="abstext"...

ea0014p103 | (1) | ECE2007

Prognostic value of anti-thyroperoxidase antibodies in high malignancy degree breast cancer

Fiore Emilio , Giani Claudio , Giustarini Elisa , Muller Ilaria , Mammoli Claudia , Campani Daniela , Roncella Manuela , Fustaino Loredana , Pinchera Aldo

A high incidence of serum anti thyro-peroxidase antibodies (TPOAb) has been found in breast cancer (BC). Aim of this study was to evaluate the predictive value of TPOAb in BC. The study group included 47 women submitted to mastectomy for high malignancy degree BC (tumor size >5 cm and/or n° lymph-nodes >3), followed for 5 years. No patient had distant metastases. All were evaluated for thyroid disorders after breast surgery and before any anti-tumoral adjuvant the...

ea0081rc11.1 | Rapid Communications 11: Thyroid 2 | ECE2022

Impact of Covid-19 disease on thyroid function: longitudinal study

Muller Ilaria , Varallo Matteo , Daturi Anita , E Re Tiziana , Dazzi Davide , Longari Virgilio , Gori Andrea , Mantovani Giovanna , Arosio Maura , Salvi Mario

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) affects thyroid function with different mechanisms: non-thyroidal illness syndrome (NTIS), direct infection of thyroid gland and cytokine storm. We provided the first description of painless atypical thyroiditis coexisting with NTIS in patients hospitalised for moderate-to-severe Covid-19 disease. We aimed to: 1) correlate thyroid dysfunction with Covid-19 disease severity;...

ea0081rc11.2 | Rapid Communications 11: Thyroid 2 | ECE2022

Subacute thyroiditis (SAT) during the COVID-19 pandemic: preliminary data from the “ESE Covid Grant 2021” project

Loiacono Simona , Zanni Eleonora , Sueri Roberta , De Vincentis Sara , Laura Monzani Maria , Di Marco Francesco , Muller Ilaria , Simoni Manuela , Santi Daniele , Brigante Giulia

Introduction: A possible association between the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 pandemic, in terms of infection and/or vaccination, and subacute thyroiditis (SAT) has been recently reported. Although a higher SAT incidence in pandemic has been described, data are still conflicting.Aim: To determine SAT incidence in Italy during the SARS-CoV-2 pandemic and to characterize clinical peculiarities and response to medical treatment...

ea0050p399 | Thyroid | SFEBES2017

Autoantibodies to the thyrotropin receptor in Alemtuzumab-induced thyroid autoimmunity: determination of their biological activity, and possible role as predictive marker of disease

Muller Ilaria , Willis Mark , Healy Sarah , Nasser Taha , Zhang Lei , Draman Mohd Shazli , Taylor Peter , Robertson Neil , Ludgate Marian , Dayan Colin

Background: Alemtuzumab (ALTZ) is a humanised monoclonal anti-CD52 antibody used as effective treatment for relapsing/remitting multiple sclerosis (MS), causing panlymphopenia with subsequent lymphocyte repopulation. Unfortunately, around 40% of patients develop secondary humoral autoimmunity, mainly affecting the thyroid gland. Anti-thyrotropin-receptor (TSHR) autoantibodies (TRAb) can stimulate (TSAb), block (TBAb) or not affect (‘neutral’) TSHR function, with TSAb...