ea0010p27 | Cytokines, growth factors, growth and development | SFE2005
Stammers R
, Robinson C
, Forster M
, Mulloy B
, Rafferty B
VEGF is an endothelial-cell specific mitogen and is a critical regulator of developmental and reproductive angiogenesis. VEGF165 is the most abundant isoform, with the N-terminal 110 aa domain containing the receptor binding site and the C-terminal 55 aa domain containing a heparin-binding site. The activity of the molecule is mediated through its interaction with two main receptors, VEGFR-1 and VEGFR-2, the binding to which is modulated by both cell surface-associated glycosa...