ea0099oc13.2 | Oral Communications 13: Late Breaking | ECE2024
Sonmezoglu Kutuk Irem
, Akı Senay
, Demirel Ali Haydar
, Mumusoglu Sezcan
, Ciftci Turkmen Turan
, Yildiz Bulent
Background and Aim: Humanin is a mitochondria-derived peptide (MDP) secreted in response to oxidative stress and linked to diverse cellular processes including inflammation and insulin resistance. Humanin has been shown to be downregulated in polycystic ovaries and exogenous humanin supplementation has attenuated insulin resistance and ovarian morphological abnormalities in a PCOS rat model. The aim of this study was to investigate the role of humanin in the pathophysiology of...