Searchable abstracts of presentations at key conferences in endocrinology

ea0025p317 | Thyroid | SFEBES2011

Anaplastic thyroid carcinoma presenting with stridor after ablative radioiodine therapy for Graves’ disease

Kalathil Sajid , Munir Atif , Nag Sath

Anaplastic carcinoma accounts for <5% of thyroid cancer. The simultaneous occurrence of anaplastic carcinoma (ATC) and Graves’s thyrotoxicosis is extremely uncommon with only six cases described in the literature.A 73-year-old female presented with weight loss and atrial fibrillation. Investigations showed TSH-0.02 mU with T4-40 pmol/l and T3-16 pmol/l suggesting thyrotoxicosis.There was no thyromegaly or orbitopathy. TBII was elevated at 10.3 U...

ea0022p16 | Adrenal | ECE2010

Secondary adrenal failure due to sepsis

Munir Atif , Nag Sath , Bilous Rudy

Introduction: Hypothalamic–pituitary adrenal axis dysfunction is common in severely ill patients. Even slight impairment of adrenal response to severe illness can increase morbidity and mortality. Relative adrenal insufficiency has been associated with severe sepsis.Case report: We report a case of 48-year-old lady who was admitted with septic shock secondary to epiglottitis requiring intubation and intensive care. Short synacthen test performed in ...

ea0021p246 | Pituitary | SFEBES2009

Management of diabetes insipidus during pregnancy

Munir Atif , Santhakumar Anjali , Conolly Vincent

Introduction: Diabetes insipidus can complicate up to 1 in 30 000 pregnancies and has a variety of causes, some that predate the pregnancy and others that begin during gestation. In addition, women can experience diabetes insipidus de novo in pregnancy through the actions of placental vasopressinase, which causes accelerated degradation of vasopressin. This form of diabetes insipidus may be associated with increased complications of pregnancy, including pre-eclampsia. M...

ea0021p398 | Thyroid | SFEBES2009

Dilated cardiomyopathy and atrial fibrillation secondary to resistance to thyroid hormone

Ullah Arif , Munir Atif , Nag Sath

Background: Resistance to thyroid hormone (RTH) is a rare autosomal dominant condition of altered tissue responsiveness to thyroid hormone (TH) characterised by elevated serum FT4 and FT3 and non-suppressed TSH levels caused by mutation in the thyroid receptor (TR) β gene. Different isoforms of TR are expressed in the heart and regulate genes that encode structural and regulatory proteins. The syndrome is characterised by a variable clinical phenotyp...

ea0031p388 | Thyroid | SFEBES2013

Myxedema Coma: an uncommon presentation of a common thyroid problem

Munir Atif , Hutchison Caroline , Kumar Balakrishna , Anthony Sony

Myxedema coma has very high mortality and should be suspected in an acutely unwell patient presenting with depressed mental status who is hypothermic, bradycardic and or hypotensive. Myxedema coma may be the first presentation of people with undiagnosed hypothyroidism. Definitive management is with thyroid hormone but supportive measures, identification and treatment of precipitating factors in an appropriately safe environment are vital. There is no consensus about preferred ...

ea0021p334 | Steroids | SFEBES2009

A rare cause of massive bilateral adrenal enlargement complicating management of congenital adrenal hyperplasia

Nag Sath , Munir Atif , Ullah Arif , Santhakumar Anjali

A 33-year-old lady presented to the surgeons with history of abdominal pain. CT scan abdomen done revealed massive adrenal enlargements reported as adrenal myelolipomas (left gland measuring 8.0×10.9×11.8 cm and multifocal lesions on the right with the larger one measuring 5.2×4.3×3.6 cm). She was referred to the endocrinology team where further history was elicited. She had been diagnosed as a child to have congenital adrenal hyperplasia (CAH) but was lost...

ea0021p401 | Thyroid | SFEBES2009

Management and follow up of post-operative hypocalcemia after thyroidectomy: a pilot study

Santhakumar Anjali , Munir Atif , Durning Pat , Nag Sath

Background: Although hypocalcemia is common post thyroidectomy, no national guidelines pertain to its management.Long-term treatment with calcium and vitamin D replacement predispose patients to nephrocalcinosis and should be avoided in the absence of a clear indication.Aim: To identify the incidence and management of post-operative hypocalcemia following thyroidectomy in a UK teaching hospital with view to formulating management g...

ea0034oc6.5 | Clinical | SFEBES2014

Effectiveness of metyrapone in 195 patients with Cushing's syndrome

Daniel Eleni , Aylwin Simon , Mustafa Omar , Ball Steve , Munir Atif , Boelaert Kristien , Chortis Vasileios , Cuthbertson Daniel J , Daousi Christina , Rajeev Surya , Davis Julian , Cheer Kelly , Drake William , Gunganah Kirun , Grossman Ashley , Gurnell Mark , Powlson Andrew , Karavitaki Niki , Huquet Isabel , Kearney Tara , Mohit Kumar , Meeran Karim , Hill Neil , Rees Aled , Trainer Peter J , Lansdown Andrew J , Minder Anna-Elisabeth H , Newell-Price John

Background: Metyrapone is widely used in the UK for the control of cortisol excess in Cushing’s syndrome, but its use is not standardised. There are a few reports published on metyrapone use, mostly containing small patient numbers.Method: A retrospective survey was conducted across 13 tertiary centres. Using a standardised proforma, extensive data including monitoring and safety information were collected for patients with Cushing’s syndrome o...