Searchable abstracts of presentations at key conferences in endocrinology

ea0013p328 | Thyroid | SFEBES2007

T3 rather than TSH mediates the effects of altered thyroid status on bone turnover in man

Murphy Elaine , Williams Graham Richard

Recent controversial studies in mice imply that TSH inhibits bone remodelling, suggesting TSH-deficiency rather than thyroid hormone excess causes bone loss in thyrotoxicosis. Measurement of the TRH-stimulated rise in TSH following three days administration of graded doses of T3 is the gold-standard for determining resistance to thyroid hormone (RTH). During this test, T3 excess coupled with suppressed TSH should induce high bone turnover, whilst administration of TRH causes a...

ea0025oc4.3 | Bone and diabetes | SFEBES2011

Rapid bone turnover responses to increased hypothalamic–pituitary–thyroid-axis activity are mediated by thyroid hormones

Gogakos Apostolos , Murphy Elaine , Bassett Duncan , Williams Graham

Increased hypothalamic–pituitary–thyroid (HPT) axis activity results in high bone turnover. T3 stimulates osteoblast and osteoclast activities, whereas TSH is proposed to inhibit bone turnover directly. Resolving the relative importance of T3 and TSH is complicated by their physiological inverse relationship. We studied 10 controls and 4 patients with resistance to thyroid hormone (RTH), in which mutation of thyroid hormone receptor beta (THR...

ea0028p343 | Thyroid | SFEBES2012

Evaluation of adjuvant lithium treatment in patients receiving radioactive iodine for hyperthyroidism: a retrospective cohort study

Patel Miraj , Nijher Gurjinder , Misra Shivani , Murphy Elaine , Meeran Karim , Martin Niamh

Lithium increases retention of Iodine-131 in the thyroid gland and inhibits thyroid hormone release following radioactive iodine (RAI) administration. However, outcomes of studies of the effects of lithium on the efficacy of RAI are conflicting. The aim of this study was to assess whether adjuvant lithium increases the efficacy of RAI treatment in hyperthyroidism. A retrospective cohort study was performed of 204 hyperthyroid patients (163 Graves’ disease, 26 toxic multin...

ea0025oc1.1 | Young Endocrinologists prize session | SFEBES2011

Thyroid hormones in the euthyroid range predict subsequent body mass composition in women: the OPUS study

Rao Preethi , Williams Graham , Murphy Elaine , Reid David , Roux Christian , Felsenberg Dieter , Gluer Claus , Eastell Richard , Razvi Salman

Background: Thyroid disease is associated with BMI with hyperthyroidism causing weight loss and hypothyroidism leading to weight gain. However, the relation of body weight distribution to thyroid function in euthyroid individuals is unclear. This study assessed body composition in euthyroid women.Methods: Euthyroid women (n=1072) from the Osteoporosis and Ultrasound Study (OPUS), a population based cohort study recruited participants from 5 Europe...

ea0015oc33 | Thyroid | SFEBES2008

Effect of thyroid status on the skeleton in post-menopausal women: the OPUS study

Murphy Elaine , Gluer Claus C , Reid David M , Felsenberg Dieter , Roux Christian , Eastell Richard , Williams Graham R

OPUS is a population-based prospective cohort study of post-menopausal women from five European cities. We investigated whether TSH, fT4 and fT3 are associated with fracture risk, bone mineral density (BMD) at hip and spine, bone formation (osteocalcin, procollagen type 1 N-terminal propeptide), bone resorption (N- and C-telopeptides of type 1 collagen, NTX, CTX), pulse rate, grip strength and balance. Vertebral fractures were determined at baseline and 6 years follow-up. Usin...

ea0028oc1.3 | Young Endocrinologists prize session | SFEBES2012

Effect of selenium status on the skeleton in post-menopausal women: the OPUS study

Gogakos Apostolos , Hoeg Antonia , Murphy Elaine , Mueller Sandra , Reid David , Gluer Claus , Felsenberg Dieter , Roux Christian , Eastell Richard , Koehrle Josef , Schomburg Lutz , Williams Graham

T3-action is regulated by three iodothyronine deiodinases, which contain selenium in the active site. It is proposed that Se availability regulates thyroid function. OPUS is a European population-based prospective cohort study of post-menopausal women in which we showed thyroid function within the upper normal range is associated with reduced bone mineral density (BMD) and increased non-vertebral fracture risk. Using strict exclusion criteria we defined reference ranges for th...

ea0025p8 | Bone | SFEBES2011

Thyrostimulin expression and signalling in the skeleton

Bassett J H Duncan , Hernandez Rebecca , Combs Charlotte , Spek Anne van der , Yu Ming , Williams Allan , Murphy Elaine , Boyde Alan , van Zeijl Clementine J J , Boelen Anita , Williams Graham R

Hypothyroidism and thyrotoxicosis have detrimental effects on skeletal development and adult bone strength. These effects result from thyroid hormone actions in bone, although a direct role for TSH in osteoblasts and osteoclasts was postulated following analysis of TSH receptor (TSHR) null mice. This hypothesis remains controversial as other studies failed to demonstrate osteoblast or osteoclast responses to TSH in vitro. Thyrostimulin is a heterodimeric glycoprotein ho...