Searchable abstracts of presentations at key conferences in endocrinology

ea0012p92 | Reproduction | SFE2006

Continuous administration of kisspeptin-54 leads to desensitisation of the hypothalamo-pituitary-gonadal axis and testicular degeneration

Appleby GF , Thompson EL , Murphy KG , Patterson M , Bewick GA , Stamp GWH , Todd JF , Ghatei MA , Bloom SR

Kisspeptin-54 is a neuropeptide encoded by the Kiss-1 gene with an important role in the regulation of reproduction and puberty. Acute peripheral or intra-hypothalamic administration of kisspeptin-54 potently stimulates the hypothalamo-pituitary-gonadal (HPG) axis via hypothalamic gonadotrophin releasing hormone (GnRH) neurons. However, the effects of chronic continuous kisspeptin administration are poorly characterised. Our studies investigated the effects of chronic, continu...

ea0011p690 | Reproduction | ECE2006

Chronic subcutaneous administration of kisspeptin-54 causes testicular degeneration in adult male rats

Thompson EL , Murphy KG , Patterson M , Bewick GA , Jethwa PH , Stamp GWH , Todd JF , Ghatei MA , Bloom SR

The kisspeptins are KiSS-1 gene-derived peptides which signal through the G protein coupled receptor 54 (GPR54), and have recently been shown to be critical regulators of reproduction. Acute intracerebroventricular (ICV) or peripheral administration of kisspeptin to rodents and primates, and peripheral administration to humans, stimulates the hypothalamic-pituitary gonadal (HPG) axis. This effect is thought to be mediated via the hypothalamic gonadotrophin-releasing hormone (G...

ea0011p681 | Reproduction | ECE2006

Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males

Dhillo WS , Chaudhri OB , Patterson M , Thompson EL , Murphy KG , Badman MK , McGowan BM , Amber V , Patel S , Ghatei MA , Bloom SR

Mutation of the GPR54 receptor is associated with a failure of reproductive function. The endogenous neuropeptide agonist for GPR54, kisspeptin, potently stimulates the hypothalamic-pituitary-gonadal (HPG) axis in rodents and primates.Objective: The present study was designed to determine the effects of elevating circulating kisspeptin levels on LH, FSH and testosterone in male volunteers.Method: Study (i) Volunteers were infused w...

ea0011p689 | Reproduction | ECE2006

Plasma kisspeptin is a novel tumour marker in patients with gestational trophoblastic neoplasia

Dhillo WS , Savage P , Murphy KG , Chaudhri OB , Patterson M , Foggo VM , Dancey GS , Mitchell H , Seckl MJ , Gahtei MA , Bloom SR

Kisspeptin is a 54 amino acid peptide, encoded by the anti-metastasis gene KiSS-1, that activates the G-protein-coupled receptor, GPR54. The kisspeptin/GPR54 system is critical to normal reproductive development. KiSS-1 gene expression is increased in the human placenta in normal and molar pregnancies. Circulating kisspeptin is dramatically increased in normal pregnancy but levels in gestational trophoblastic neoplasia (GTN) have not previously been reported. The...

ea0019oc4 | Young Endocrinologist prize session | SFEBES2009

Kisspeptin potently increases reproductive hormone release in women with hypothalamic amenorrhoea: a potential novel therapy for infertility

Jayasena CN , Chaudhri OB , Nijher GK , Murphy KG , Ranger A , Lim A , Patel D , Mehta A , Todd C , Ramachandran R , Salem V , Stamp GW , Donaldson M , Ghatei MA , Bloom SR , Dhillo WS

Background: Kisspeptin is a critical regulator of normal reproductive function. In humans inactivating mutations of the kisspeptin receptor GPR54 cause hypogonadotrophic hypogonadism and pubertal failure. Activating mutations of GPR54 cause precocious puberty. Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. In rodent models of HA hypothalamic KISS1 expressi...