Searchable abstracts of presentations at key conferences in endocrinology

ea0019p259 | Pituitary | SFEBES2009

Pituitary diseases and arachnoid cysts: more than a coincidence?

Murthy NPN , Murthy A , Ashawesh K , Kulambil Padinjakara RN , Pua S , Randeva H

CASE 1: A 50-year-old male was referred to the endocrine clinic with decreased libido and erectile dysfunction. Physical examination showed normal sense of smell, testicular size and secondary sexual characters. Investigations revealed low testosterone (10.6 mmol/l), SHBG 29.6 nmol/l, LH (6 IU/l) and FSH (7 IU/l) with high prolactin (4000 mU/l). The rest of the anterior pituitary hormones were normal. A MRI scan of the head showed a pituitary microadenoma with arachnoid cyst i...

ea0019p15 | Bone | SFEBES2009

Novel mutation of the COL1A2 gene in a patient with osteogenesis imperfecta

Pua S , Ashawesh K , Murthy NPN , Randeva H

Introduction: Osteogenesis imperfecta (OI) is classified on the basis of molecular genetics, mode of inheritance, clinical and radiological findings. The genes implicated are either COL1A1 or COL1A2. We report a case of a novel mutation of OI in the COL1A2 gene.Case: A 24-year-old teacher with type 1 Diabetes Mellitus, presented to our Endocrine Clinic with recurrent fractures since childhood. At 7 months old, she fractured her left leg. At...

ea0019p16 | Bone | SFEBES2009

Familial hypocalciuric hypercalcaemia and pregnancy outcome

Murthy A , Murthy NPN , Ashawesh K , Kulambil Padinjakara RN , Anwar A

Introduction: Hypercalcaemia during pregnancy poses a risk to both the mother and foetus and can present a complex management issue. Although hypercalcaemia from any cause can occur during pregnancy, primary hyperparathyroidism is the most common cause but other rarer cause such as familial hypocalciuric hypercalcaemia (FHH) should be ruled out. Although usually posing no risk to the mother, infants of mothers with the disease are at risk for neonatal hypocalcaemia, and seizur...

ea0019p263 | Pituitary | SFEBES2009

Plasmacytoma: an unusual cause of a pituitary mass lesion

Murthy NPN , Ashawesh K , Kulambil Padinjakara NPN , Syed A , Randeva H

Introduction: Plasma cell neoplasms include a variety of clinicopathologic entities including; multiple myeloma, solitary plasmacytoma of bone and extramedullary plasmacytoma. Plasma cell neoplasms of the pituitary area are very rare, with only 19 cases in the literature. We report a rare case of multiple myeloma presenting with parasellar mass.Case: A 44-year-old lady was admitted with sudden onset of diplopia and blurring of vision. She also mentioned ...

ea0019p298 | Reproduction | SFEBES2009

Successful pregnancy and delivery of triplets in patient with BMI of 80

Padinjakara RN Kulambil , Ashawesh K , Murthy NPN , Anwar A

Introduction: It is rare for patients with morbid obesity to become pregnant without assisted reproductive support. Spontaneous conception of triplets and their successful delivery by caesarean section is hitherto unreported. We report the case of world’s heaviest mother to undergo caesarean section with good outcome for mother and the babies.Case history: A 24 year old lady was seen in the antenatal clinic at 11 weeks of pregnancy. She weighed 140 ...

ea0019p378 | Thyroid | SFEBES2009

Severe dilated cardiomyopathy and hyperthyroidism

Ashawesh K , Padinjakara RN Kulambil , Murthy NPN , Sankar S , Syed A

Introduction: Dilated cardiomyopathy is an uncommon, but well recognized, manifestation of thyrotoxicosis. However, hyperthyroidism presenting with dilated cardiomyopathy is very rare. We describe an unusual case of dilated cardiomyopathy as the initial manifestation of Graves’ hyperthyroidism.Case: A 61-year-old man of Malaysian origin, with no significant past medical history, was admitted with two month history of worsening shortness of breath, o...

ea0011p141 | Clinical case reports | ECE2006

A rare cause of thyrotoxicosis and hypercalcemia

Murthy NPN , Prasad Y , Thomas M , Fiad T

A32 year old lady was admitted with symptoms of palpitations, tremors, insomnia, heat intolerance, weight loss and excessive perspiration for 4 weeks. Worsening of these symptoms with vomiting prompted the admission. She had similar episode 7 yrs ago following the birth of her child when a provisional diagnosis of postpartum thyrotoxicosis was made but lost follow up with in 2 weeks. She works as a carer looking after mentally handicapped children. Her mother suffers from hypo...

ea0019p154 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Prevalence of eating disorder characteristics in the morbidly obese patients

Baker C , Noushad F , Padinjakara RN Kulambil , Ashawesh K , Murthy NPN , Kumar S , Anwar A

Objectives: To find out the proportion of patients with morbid obesity who may have co-existing eating disorders, using EAT-26 (Eating Attitude Test) Questionnaire.Method: All patients who attended the specialist morbid obesity clinic, between January 2005 and December 2007, at a university hospital were included in the study. EAT -26 questionnaires were given to the patients at the time of their referral. The specialist dietician took responsibility for...

ea0019p181 | Endocrine tumours and neoplasia | SFEBES2009

Neuroendocrine gastric carcinoma and MEN 1: a novel mutation of MEN 1 gene

Altaf Q , Ashawesh K , Acors N , Murthy NPN , Sankar S , Syed A

Case: We are describing a case of 57-year-old gentleman who initially presented to gastroenterology clinic with iron deficiency anaemia (Hb – 11, Ferritin – 5) and 2 stone weight loss. An OGD was performed which demonstrated a polypoidal tumor in the distal body of stomach. Histology proved it to be carcinoid tumor. Staging CT thorax/abdomen showed marked gastric rugal thickening involving the fundus and body of the stomach with no extra mural spread, nodal disease o...

ea0019p221 | Neuroendocrinology and behaviour | SFEBES2009

Hypomania in a patient receiving testosterone replacement

Wong YL , Kulambil Padinjakara RN , Ashawesh K , Murthy NPN , Syed A , Sankar S

Introduction: Testosterone treatment can improve symptoms in hypogonadal men with depression. It is also known to induce aggressive behaviour hypomania and even mania. When patients with bipolar disorder and hypogonadism present with manic symptoms it is particularly difficult to decide whether testosterone should be discontinued or not during manic phase of the illness.Case: A 39 years old Caucasian man was diagnosed with isolated hypogonadotropic hypog...