Searchable abstracts of presentations at key conferences in endocrinology

ea0081ep1009 | Thyroid | ECE2022

Subacute thyroiditis following asymptomatic COVID-19 case report

Ilie Iuliana , Musat Madalina , Oprea Luciana

Subacute thyroiditis (SAT) is a relatively uncommon and self-limited cause of thyrotoxicosis of viral or post-viral origin. During the COVID-19 pandemic a thyroid impact was also considered due to the potential of SARS-CoV-2 virus to cause multiorgan effects. Several SAT cases associated with SARS-CoV-2 infection or vaccination were recently reported in the literature. We present the case of a 52-year-old female who presented with neck pain, fever, asthenia, and malaise for ap...

ea0070aep706 | Pituitary and Neuroendocrinology | ECE2020

Microprolactinoma, PCOS Or stress induced hyperprolactinemia? – case report

Oprea Luciana , banica andreea , Ilie Iuliana , Iordachescu Carmen , Musat Madalina

Hyperprolactinemia is one of the most common problems in clinical endocrinology. It relates with various etiologies (physiological, pharmacological, pathological), the clarification of which requires careful history taking and clinical assessment.We present the case of a 15-year-old girl, with history of secondary amenorrhea and headache in the presence of mildly elevated prolactin level, diagnosed as a microprolactinoma on MRI scan (4–5 mm) and tr...

ea0063p251 | Pituitary and Neuroendocrinology 1 | ECE2019

Primary infundibulohypophysitis in a young man with DI and Hypogonadism

Ilie Iuliana , Musat Madalina , Hortopan Dan , Iordachescu Carmen , Mitrea Dan , Banica Andreea , Oprea Luciana

Primary hypophysitis is a rare inflammatory condition which is mostly encountered in women. It represents 0.2–0.8% of pituitary pathologies and its annual incidence is estimated at 1 case per 9 million inhabitants. We present the case of a 28-year-old male, smoker, with sudden onset decreased libido, polyuria and polydipsia. At presentation he had an epicranial lipoma with and no other suggestive clinical signs. Biochemistry revealed hypernatremia 146 nmol/L, low testoste...

ea0037ep1278 | Clinical Cases–Thyroid/Other | ECE2015

Autoimmune polyglandular syndrome: case report series

Nan Raluca , Guja Cristian , Caragheorgheopol Andra , Manda Dana , Radulian Gabriela , Musat Madalina

Introduction: The polyglandular autoimmune syndromes (PAS) are rare conditions characterised by the failure of several endocrine glands sometimes associated with other non-endocrine autoimmune diseases. There are four categories of PAS: PAS-I includes at least two out of: mucocutaneous candidiasis, hypoparathyroidism and adrenocortical failure. PAS-II comprises of Addison’s disease, autoimmune thyroid disease and/or type 1 diabetes (Carpenter’s syndrome). PAS-III is ...

ea0022p247 | Clinical case reports and clinical practice | ECE2010

A tale to tell: how lupus led to Graves' disease

Musat Madalina , Giurca Camelia , Aflorei Daniela , Lupu Anca , Dumitrascu Anda , Milicescu Mihaela , Danciulescu Rucsandra , Poiana Catalina

Introduction: Despite the presence of antinuclear (ANA) and anti DNA antibodies in Graves’ disease, the association with Systemic Lupus Erythematosus (SLE) is rare. Responsible for this association seem to be mutations in the PTPN22 gene.Case Report: We report a case of a 27-year-old woman, who presented in January 2009 in our department, at 6 months postpartum, after extensive investigations for autoimmune disease. She had negative results for poly...

ea0049ep1063 | Pituitary - Clinical | ECE2017

“Toxic” Goiter Reveals Cushing’s Disease

Musat Madalina , Hortopan Dan , Oprea Luciana , Duceac Andreea , Manda Dana , Caragheorgheopol Andra , Iordachescu Carmen , Tupea Claudiu , Ciubotaru Vasile

Case presentation: Mrs. S presented in an endocrine clinic for fatigue, weight loss, restlessness and goiter. She was obese with a BMI of 51 kg/mp, hypertensive and had a medium size, nontender goiter. Lab test revealed hyperglycaemia, suppressed TSH (<0.03mUI/L), on two separate occasions, mid-normal fT4 and T3. Thyroid ultrasound revealed multinodular goiter. A diagnosis of polynodular goiter with subclinical hyperthyroidism was made and patient was commenced on thiamazo...

ea0026p89 | Endocrine tumours and neoplasia | ECE2011

The management of thyroid nodule in a patient with a non-thyroid primary cancer

Baloescu Rene , Carsote Mara , Trifanescu Raluca , Musat Madalina , Danciulescu-Miulescu Ruxandra , Ioachim Dumitru , Terzea Dana , Poiana Catalina

Introduction: The management of a thyroid nodule in a patient who is newly diagnosed with an active cancer depends not only of the thyroid disease its self but also of the prognosis of the second neoplasia.Aim: We present a case of a male who was admitted to an endocrinologist for a thyroid nodule evaluation.Case presentation: B.C., 66-year-old male patient, smoker from the last 17 years, was treated with thyamazol for hyperthyroid...

ea0081ep985 | Thyroid | ECE2022

An unusual association between medullary thyroid carcinoma and testicular seminoma: Chemotherapy-induced complications, genetic predisposition or random relationship?

Septar AIlin , Smarandache Romeo , Niculescu Dan Alexandru , Goldstein Andrei , Braha Elena , Muresan Andrei , Caragheorgheopol Andra , Terzea Dana , Constantin Teodor , Buduluca Larisa , Musat Madalina

Medullary thyroid carcinoma (MTC) is a rare malignancy arising from parafollicular C cells of the thyroid gland, sometimes due to germline mutations in the RET protooncogene. Testicular cancer is the most common malignancy in men aged 15 - 40 years with survival rates improved by the introduction of cisplatin therapy in the late 1970s. Nonetheless, platinum-based chemotherapy was shown to increase the risk of a solid second cancer with substantially increased site-specific ris...

ea0037ep47 | Adrenal cortex | ECE2015

A challenging case of paraneoplastic Cushing's syndrome

Mazilu Adina , Gheorghiu Mona , Musat Madalina , Ranetti Aurelian-Emil , Mazilu Victor-Catalin , Tanase Narcis , Petrescu Razvan , Ciuche Adrian , Tudose Augustin , Vasilescu Florina , Ardeleanu Carmen

Introduction: Paraneoplastic Cushing’ syndrome (CS) represents 5–10% of all CS and has a severe prognosis due to severe metabolic imbalance, denutrition, associated infections, and progression of tumoural underlying pathology.A 67 years old woman presented with mental confusion, progressive weight loss, severe oedema and kypokalaemia, without typical features of Cushing or hyperpigmentation. Investigations revealed paraneoplastic Cushing’s...

ea0073aep695 | Thyroid | ECE2021

-Systemic erdheim-chester disease associated with braf-positive papillary thyroid carcinoma

Ilie Iuliana , Francois Emile Jean , Chereau Natalie , Haroche Julien , Buffet Camille , Deniziaut Gabrielle , Constantin Teodor , Bercu Bogdan , Oprea Luciana , Banica Andreea , Musat Madalina

Erdheim-Chester disease (ECD) is a rare histiocytic neoplasm with distinctive clinical and immunophenotypic features, involving somatic mutations of BRAF and activation of MAPK pathway. Other BRAF mutated neoplasms such as papillary thyroid carcinoma (PTC), may also occur synchronous with EDC. There are several reports in the literature of concurrent Langerhans Cell Histiocytosis (LCH) and PTC which suggests that the association is not random, howeve...