Searchable abstracts of presentations at key conferences in endocrinology

ea0016p21 | Adrenal | ECE2008

11β-hydroxysteroid dehydrogenase 2 activity is elevated in extreme obese subjects and negatively associated with insulin sensitivity

Mussig Karsten , Remer Thomas , Haupt Axel , Gallwitz Baptist , Fritsche Andreas , Haring Hans-Ulrich , Maser-Gluth Christiane

Objectives: Alterations in glucocorticoid (GC) metabolism may contribute to the development of obesity and insulin resistance. We aimed to study the role of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) in human adiposity, paying special attention to the association between altered GC metabolism and insulin sensitivity.Design: In 24-h urine samples of 72 extremely obese (mean BMI 45.5±1.1 kg/m2), but otherwise healthy patie...

ea0016p121 | Clinical cases | ECE2008

Primary squamous cell carcinoma of the thyroid

Mussig Karsten , Dahm Julia , Koitschev Assen , Horger Marius , Muller Mark , Bares Roland , Wehrmann Manfred

Background: Primary squamous cell carcinomas of the thyroid are uncommon entities with less than 100 cases described in the literature.Case report: We report on the imaging findings in a rare case of primary squamous cell carcinoma of the thyroid that was found to be the primary tumour of humerus and cervical lymph node metastases. Other sources of squamous cell cancer were ruled out by a careful search, including whole body computed tomography (CT), pos...

ea0016p727 | Thyroid | ECE2008

Hashimoto’s thyreoiditis is associated with an increased occurrence of deficits in attention testing compared to patients with other thyroid illnesses

Mussig Karsten , Leyhe Thomas , Weinert Claudia , Saur Ralf , Klingberg Stefan , Gallwitz Baptist

Objectives: Experimental and clinical data point to an involvement of the central nervous system in Hashimoto’s thyroiditis (HT) independent of thyroid dysfunction. The neuropsychological function of patients with HT has not been systematically evaluated yet.Design: In the present prospective study, neuropsychological testing was performed in 26 euthyroid patients with HT compared to 25 euthyroid patients with hormonal treatment for goitre or after ...

ea0067o59 | Oral Presentations | EYES2019

Reduced insulin clearance relates to increased liver fat content in recent-onset type 2 diabetes and to impaired glucose control in recent-onset type 1 diabetes

Antoniou Sofia , Zaharia Oana P , Bobrov Pavel , Strassburger Klaus , Karusheva Yanislava , Bodis Kalman , Kupriyanova Yuliya , Burkart Volker , Hwang Jong-Hee , Mussig Karsten , Gastaldelli Amalia , Roden Michael , Szendroedi Julia

Objective: Insulin clearance can be lower in longstanding insulin-resistant states, whereas hepatic insulin kinetics are not yet clear in newly diagnosed diabetes mellitus.Methods: Volunteers with type 1 (T1D; n=276, 66% male) or type 2 diabetes (T2D; n=451, 69%) and glucose-tolerant humans (CON; n=143, 65%) underwent hyperinsulinemic-euglycemic clamps to assess whole-body insulin sensitivity (M-value) and whole-body insulin cl...