Searchable abstracts of presentations at key conferences in endocrinology

ea0016p584 | Paediatric endocrinology | ECE2008

Growth hormone deficient children born small-for-gestational-age need higher than replacement dose of hGH for successful treatment

Peter Ferenc , Luczay Andrea , Solyom Eniko , Gellen Balazs , Niederland Tamas , Felszeghy Eniko , Sagodi Laszlo , Solyom Janos , Muzsnai Agota

Growth hormone deficient (GHD) children born small-for-gestational-age (SGA) receive the same hGH dose as the children born with appropriate weight/length for gestational age (AGA). There are very few data on their lower growth response to the usual GH replacement dose. The aim of this multi-centre retrospective study is to analyse the hGH dose dependency of GHD children with SGA.SGA was defined as a birth weight/length below – 2 SD for gestational ...

ea0070aep1064 | Hot topics (including COVID-19) | ECE2020

Pharmacokinetics and pharmacodynamics of macimorelin acetate (AEZS-130) in paediatric patients with suspected growth hormone deficiency (GHD)

Csákváry Violetta , Muzsnai Agota , Raduk Dmitri , Chaychenko Tetyana , Bentz Damholt Birgitte , Bakhtadze Bagci Ekaterine , Teifel Michael , Ammer Nicola

Growth hormone deficiency (GHD) in children is a rare, aetiologically diverse condition that results in growth failure and short stature. Inadequate response to two different growth hormone stimulation tests (GHST) is required for the diagnosis of GHD. Macimorelin acetate, a potent, orally administered growth hormone (GH) secretagogue, is approved by the FDA and EMA for the diagnosis of adult GHD. Study AEZS-130-P01 is the first of two studies to investigate macimorelin acetat...

ea0014p585 | (1) | ECE2007

Genetic analysis of PROP1 gene in patients with childhood-onset combined pituitary hormone deficiency (CPHD)

Halász Zita , Toke Judit , Patócs Attila , Bertalan Rita , Tömböl Zsófia , Sallai Ágnes , Hosszú Éva , Muzsnai Ágota , Kovács László , Sólyom János , Fekete György , Rácz Károly

Introduction: Combined pituitary hormone deficiency (CPHD) may be associated with mutations of genes coding for pituitary transcription factors, of which the PROP1 and Pit1, gene mutations have been most extensively studied. However, there are controversial data about the prevalence of these gene mutations in non-acquired childhood-onset CPHD patients.Objectives: To examine the prevalence and spectrum of PROP1 and Pit1 gene mutations in CPHD patients a m...