Endocrine Abstracts

Patients who have Sr. Prolactin level >3000 mU/l (n=24) were selected from the Biochemistry laboratory record & patients with confirmed diagnosis of prolactinoma (n=33) identified and / followed up at Endocrine Clinic between December 1999 and October 2001 were studied. The mean age of the patients were 45.03+ 14.09 years and 72% were women. Of the patients diagnosed to have prolactinoma, 16 had microprolactinoma. 16 had macroprolactinoma and 1 had stalk disconnection. ...

In breast cancer associations between p160 co-activator proteins and the development of resistance to endocrine treatment have been shown. We hypothesized that nuclear co-regulatory proteins may interact with non-steroid receptors. We investigated the effect of silencing the co-activator, SRC-1, on tumour cell growth in vitro. We also examined the MAPK activated transcription factors, Ets, as possible interaction proteins of the co-activator SRC-1 in human breast cancer. The e...

Joint UK guideline (2006) recommends that routine testing of thyroid function (TFT) in patients admitted acutely to hospital is not warranted unless specific clinical indications exist. Despite this, TFT is frequently requested during acute medical admission. In our previous audit in 2002, during a 1 month period from 18th September, 458 subjects were admitted to medical assessment unit (MAU) and 183 (40%) were offered TFT. 39 (29%) results were beyond the laboratory reference...