Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep31 | Adrenal cortex (to include Cushing's) | ECE2017

The role of CYP11B2 polymorphism in the pathogenesis of hypertension in patients with adrenal incidentaloma

Zukowski Lukasz , Wawrusiewicz-Kurylonek Natalia , Mysliwiec Janusz , Gorska Maria

Background: Significant prevalence of hypertension in the world’s population and its consequences tend to an intensive search for pathogenesis and etiology of this disease. Epidemic of hypertension is accompanied by an epidemic of adrenal incidentaloma and grows in direct proportion to patients age. Polymorphism of aldosterone synthase (CYP11B2) in -344th region of promoter seems to have much in common with hypertension and adrenal incidentaloma.Aim...

ea0041ep37 | Adrenal cortex (to include Cushing's) | ECE2016

CYP11B2 polymorphism affects the aldosterone – renin ratio?

Zukowski Lukasz , Mysliwiec Janusz , Wawrusiewicz-Kurylonek Natalia , Gorska Maria

Introduction: Nowadays is believed that primary aldosteronism (PA) is the most frequent cause of secondary hypertension and reaches 10% of whole hypertensive population. The activity of the mineralocorticoid hormone may be change by polymorphism of aldosterone synthase gene (CYP11B2) e.g. in promoter -344T/C region. Aim of this study was to find differences in baseline plasma aldosterone concentration (PAC), plasma renin activity (PRA), aldosterone – renin ratio (ARR) and...

ea0035p1041 | Thyroid (non-cancer) | ECE2014

The induction of hyperthyroidism in patient with non-toxic goiter after radioiodine therapy: a case report

Abdelrazek Saeid , Mysliwiec Janusz , Szumowski Piotr , Kraszynska Anna

Two female patients aged 44 (PtA) and 68 years old (PtB) with non-toxic nodular goitre for more than 10 years were treated with radioiodine therapy. High resolution ultrasonography show enlarged thyroid glands 50 ml, with two nodules in left and right lobe in PtA and 58 ml with one nodule in the left lobe in PtB. Serum TSH, fT4 and fT3 were in normal ranges. Malignancy was ruled out by ultrasound-guided fine-needle aspiration biopsy. In PtA thyroid radioi...

ea0020p62 | Thyroid | ECE2009

Soluble CD40 and its ligand CD154 in patients with Graves’ orbitopathy during combined therapy with corticosteroids and teleradiotherapy

Mysliwiec Janusz , Waligorski Dariusz , Nikolajuk Agnieszka , Gorska Maria

It was shown recently that orbital fibroblasts express intensively CD40 and its ligation stimulates proinflammatory cytokines, glicosoaminoglycans and PGE2 production. CD40/CD154 interaction in the pathogenesis of Graves’ orbitopathy (GO) is suggested an important pathway of T cells induced fibroblast activation and proliferation.Aim: To assess the role of CD40/CD154 interaction in GO pathogenesis and to estimate usefulness of soluble CD4...

ea0014oc5.7 | Thyroid basic | ECE2007

The 1188A/C polymorphism of IL-12 gene in Graves’ disease

Wawrusiewicz-Kurylonek Natalia , Gorska Maria , Mysliwiec Janusz , Kretowski Adam Jacek

Background and aims: Interleukin-12 (IL-12) is a pro inflammatory cytokine, which was suggested to play a key role in the pathogenesis of Th1-cell-mediated autoimmune diseases. The aim of our study was to estimate the association of 1188A/C polymorphism of IL12B gene with the predisposition to Graves’ disease (GD) in Polish population.Materials and methods: The study was performed in the group consisting of 245 individuals with GD sequentially recru...

ea0037ep931 | Thyroid (non-cancer) | ECE2015

The efficacy of radioiodine therapy in patients with non-toxic nodular goitre with large cold nodule

Abdelrazek Saeid , Szumowski Piotr , Siewko Katrzyna , Mysliwiec Janusz , Szelachowska Malgorzata , Garkowski Marcin

Most of the patients with the benign cold nodule refuse surgical operation. Radioiodine therapy (RIT) is the choice for these patients. The aim of our study was to evaluate the efficacy of radioiodine therapy to reduce thyroid volume in patients with cold nodule by the use of two doses of radioiodine.Methods: We treated 40 patients with non-toxic nodular goitre with large cold nodule, aged 18 and 48 years; initial 24 h radioiodine uptake (RAIU) was range...

ea0035p1023 | Thyroid (non-cancer) | ECE2014

Is Clinical Activity Score (CAS) a sufficient indicator of the response to therapy with i.v. methylprednisolone (MP) and external radiotherapy (RT) for Graves orbitopathy?

Palyga Iwona , Kowalska Aldona , Mysliwiec Janusz , Gajos Grazyna , Palyga Robert , Gasior-Perczak Danuta

Introduction: Treatment of Graves orbitopathy (GO) is one of the most difficult problems in clinical endocrinology. Objective: To establish the efficacy of the regime used in the treatment of GO and to analyze methods used to determine treatment effectiveness.Material: The study involved 30 patients with moderate to severe GO (according to the classification of EUGOGO) being in the active phase of GO.Method: ...

ea0032p981 | Thyroid (non-cancer) | ECE2013

The influence of single dose recombinant human thyroid-stimulating hormone on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU

Abdelrazek Saeid , Mysliwiec Janusz , Szumowski Piotr , Mojsak Malgorzata , Siewko katarzyna , Poplawska-Kita Anna

Aim: The aim of our study was to evaluate the influence of recombinant human thyroid-stimulating hormone (rhTSH) on the efficacy of radioiodine therapy in patients with non toxic nodular goitre with low RAIU.Materials and methods: The study was performed on 50 patients with non toxic nodular goitre (36 females and 14 males, aged 34–75 years) referred for radioiodine therapy. All patients had low RAIU (8–16%), 24 h after a diagnostic dose of I-1...

ea0032p415 | Diabetes | ECE2013

Association between type 1 diabetes and oral health status

Poplawska-Kita Anna , Siewko Katarzyna , Szpak Piotr , Krol Beata , Telejko Beata , Mysliwiec Janusz , Stokowska Wanda , Gorska Maria , Szelachowska Malgorzata

Aims: We assessed periodontal status in patients with type 1 diabetes and healthy individuals in relation to their glycemic control, smoking, and inflammatory biomarkers.Methods: Periodontal status was examined in 107 patients with type 1 diabetes and 40 controls, using oral hygiene index (OHI), community periodontal index (CPI) and teeth number. CPI values of 0–2 and 3–4 were classified as non-periodontitis and periodontitis respectively. Bloo...

ea0016p739 | Thyroid | ECE2008

Interleukin-6 is not essential for bone turnover in hypothyroid mice

Mysliwiec Janusz , Zbucki Robert , Winnicka Maria , Sawicki Boguslaw , Nikolajuk Agnieszka , Kaminski Karol , Mysliwiec Piotr , Musial Wlodzimierz , Bondyra Zofia , Walecki Jerzy , Gorska Maria

Interleukin-6 (IL-6) has been shown to be involved in the pathogenesis of several bone diseases characterized by an imbalance between bone resorption and formation. Lately we have published our data suggesting an important role of IL-6 in thyrotoxicosis-related osteoporosis in mice (Horm Metab Res 2007 39 1–5).Aim: The aim of the study was to estimate serum markers of bone turnover: osteoclast-derived tartrate-resistant acid phosphatas...