Searchable abstracts of presentations at key conferences in endocrinology

ea0097003 | Section | BES2023

Low-dose anti-thymocyte globulin in combination with verapamil reverses hyperglycaemia in newly diagnosed diabetic NOD mice

P. J. Martens , M. Viaene , D. Ellis , N. Geukens , C Mathieu , C. Gysemans

Background: To arrest the immune-mediated destruction of the insulin-producing pancreatic beta cells in type 1 diabetes (T1D), interventional studies have predominantly focussed on two distinct approaches: arresting the ongoing immune response or protecting the pancreatic beta cells. Recently, both approaches using respectively low-dose anti-thymocyte globulin (ATG), an immune-depleting agent, and verapamil, a calcium channel blocker with beta cell protective ...