Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1358 | Thyroid (non-cancer) | ECE2017

Safety and efficacy of cholestyramine in the adjuvant management of Graves thyrotoxicosis

Gulfam Taimur , Nag Sath

Introduction: Graves’s disease is an autoimmune condition both cell and antibody-mediated, which is associated with thyrotoxicosis and extra thyroid features.Case report: A 35-year-old female presented with symptomatic hyperthyroidism due to graves thyrotoxicosis. She developed adverse reactions, including severe dermatitis and hepatotoxicity, to two of the thionamide drugs (carbimazole and propylthiouracil). Eventually we decided for definitive tre...

ea0065cc5 | (1) | SFEBES2019

Pituitary carcinoma with hepatic metastasis hypersecreting ACTH precursors masquerading as Nelson syndrome after bilateral adrenalectomy for refractory Cushing’s syndrome

Dhakshinamoorthy Barkavi , Elsaify Wael , Nag Sath

Pituitary carcinomas are extremely rare accounting for only 0.1%–0.2% of all pituitary tumours. The diagnosis is primarily dependent on aggressive imaging characteristics and high tumour mitotic activity on histology. A 47 year old gentleman with Type 1 Diabetes presented with an apparent non-functioning pituitary macro adenoma which was resected transsphenoidally and followed by EBRT. Initial histology was negative for ACTH. He presented 2 years later with florid Cushing...

ea0038p425 | Steroids | SFEBES2015

Primary testicular lymphoma with bilateral adrenal masses and adrenal insufficiency

Artham Satish , Mamoojee Yaasir , Nag Sath

Introduction: Primary testicular lymphoma is very rare and constitutes about 2% of all extra nodal lymphomas, mostly in men above the age of 60. Bilateral adrenal masses could be due to metastatic disease, congenital adrenal hyperplasia, bilateral macro-nodular hyperplasia, adrenal adenomas, lymphomas, infiltrative diseases, amyloidosis and infections like tuberculosis. Metastasis occurs most commonly from lung, bowel, breast and pancreatic cancer. Metastasis from lymphomas is...

ea0025p317 | Thyroid | SFEBES2011

Anaplastic thyroid carcinoma presenting with stridor after ablative radioiodine therapy for Graves’ disease

Kalathil Sajid , Munir Atif , Nag Sath

Anaplastic carcinoma accounts for <5% of thyroid cancer. The simultaneous occurrence of anaplastic carcinoma (ATC) and Graves’s thyrotoxicosis is extremely uncommon with only six cases described in the literature.A 73-year-old female presented with weight loss and atrial fibrillation. Investigations showed TSH-0.02 mU with T4-40 pmol/l and T3-16 pmol/l suggesting thyrotoxicosis.There was no thyromegaly or orbitopathy. TBII was elevated at 10.3 U...

ea0022p16 | Adrenal | ECE2010

Secondary adrenal failure due to sepsis

Munir Atif , Nag Sath , Bilous Rudy

Introduction: Hypothalamic–pituitary adrenal axis dysfunction is common in severely ill patients. Even slight impairment of adrenal response to severe illness can increase morbidity and mortality. Relative adrenal insufficiency has been associated with severe sepsis.Case report: We report a case of 48-year-old lady who was admitted with septic shock secondary to epiglottitis requiring intubation and intensive care. Short synacthen test performed in ...

ea0021p398 | Thyroid | SFEBES2009

Dilated cardiomyopathy and atrial fibrillation secondary to resistance to thyroid hormone

Ullah Arif , Munir Atif , Nag Sath

Background: Resistance to thyroid hormone (RTH) is a rare autosomal dominant condition of altered tissue responsiveness to thyroid hormone (TH) characterised by elevated serum FT4 and FT3 and non-suppressed TSH levels caused by mutation in the thyroid receptor (TR) β gene. Different isoforms of TR are expressed in the heart and regulate genes that encode structural and regulatory proteins. The syndrome is characterised by a variable clinical phenotyp...

ea0074ncc15 | Highlighted Cases | SFENCC2021

A case report on rare metastic Paraganglioma with SDHB mutation

Dhakshinamoorthy Barkavi , Nag Sath , Ahmad Waquar

Paragangliomas are rare neuroendocrine tumours that originate from neural crest cells and can arise from any autonomic ganglion of the body. This is a challenging entity given the limited therapeutic options. Here, we present a rare case of metastatic Paraganglioma in a patient with a germline pathogenic succinate dehydrogenase subunit B (SDHB) mutation. A 54 year old lady was initially diagnosed with functioning bladder paraganglioma with raised metanephrine and norm...

ea0059ep82 | Neuroendocrinology and pituitary | SFEBES2018

Acromegaly due to a mixed growth hormone secreting adenoma-gangliocytoma - a rare cause of GH excess

Wood Maximilian , Varma Anil , Scoones David , Nag Sath

Adeno-gangliocytomas are rare tumours of the pituitary gland with less than 40 cases described worldwide. Due to the rarity of these tumours, treatment modalities largely follow that of conventional therapies for common pituitary lesions. Case reports on these tumours offer insight into their presentation and the effectiveness of treatment which helps guide future management. A 64-year-old man was admitted for stone fragmentation and ureteric stent insertion. During anaestheti...

ea0038p459 | Thyroid | SFEBES2015

Qualitative analysis of ultrasound reports assessing radiological descriptors of thyroid nodules – a retrospective pilot audit

Artham Satish , Mamoojee Yaasir , Jones Sue , Lal Vikram , Nag Sath

Introduction: Thyroid Ultrasound (US) is the recommended first line investigation of suspected thyroid nodules. Specific radiological features, such as micro-calcification, low echogenicity, solid consistency, heterogeneity and ill-defined margins, raise the possibility of underlying malignancy. These findings together with fine needle aspiration cytology guide the management of thyroid nodules. The aim of this audit was to evaluate the quality and adequacy of thyroid US repor...

ea0037ep265 | Calcium and Vitamin D metabolism | ECE2015

Severe refractory hypocalcaemia associated with osteoblastic metastatic breast carcinoma

Lal Vikram , Ashwell Simon , Humphreys Alison , Nag Sath

Introduction: Hypercalcaemia is well associated with metastatic malignancy. Hypocalcaemia is an uncommon complication of osteoblastic metastases and occurs most commonly with breast and prostate carcinoma.Case: A 46-year-old woman with metastatic breast carcinoma and osteoblastic skeletal metastases treated with denosumab presented with severe symptomatic hypocalcaemia. Serum calcium was persistently low with a nadir value of 1.45 mmol/l (2.2–2.6) a...