Searchable abstracts of presentations at key conferences in endocrinology

ea0037ep592 | Obesity and cardiovascular endocrinology | ECE2015

Relationship between thyroid hormone status and concomitant medication in hyperlipidaemic patients with statin induced adverse effects

Berta Eszter , Zsiros Noemi , Nagy Endre , Paragh Gyorgy , Bodor Miklos

Statins are effective treatment for the prevention of cardiovascular diseases and used extensively worldwide. However, adverse effects induced by statins are the major barrier of maximalising cardiovascular risk reduction. Hypothyroidism and administration of drugs metabolised on the same cytochrome P450 (CYPP450) pathways where statin biotransformation occurs represent a significant risk factor for statin induced adverse effects including myopathy. Simvastatin, atorvastatin a...

ea0056gp248 | Thyroid non cancer | ECE2018

Thyroid function in early-treated adult PKU patients

Sumanszki Csaba , Kiss Erika , Simon Erika , Patocs Attilla , Nagy Endre

Introduction: Phenylketonuria (PKU) is a rare inherited metabolic disorder that leads to the toxic accumulation of phenylalanine (Phe) causing usually severe mental retardation and seizures. The basis of the lifelong therapy is low in natural-protein diet and Phe-free amino acid mixtures, that provide the daily necessary amino acids, vitamins and micronutrients, such as Iodine and Selenium. It is not well known, whether the adherence to the therapy can influence the thyroid fu...

ea0081ep704 | Pituitary and Neuroendocrinology | ECE2022

Cessation of GH secretion in acromegaly without medical or surgical intervetion; Covid-postponed surgery was escaped

Erdei Annamaria , Daniel Eszter , Gazdag Annamaria , Griger Miha ly , Nagy Edit B , Nagy Endre V

Introduction: Acromegaly is usually caused by pituitary macroadenoma producing excess growth hormone. Treatment options include surgery to remove the tumor, medications, and radiation therapy.Case report: A 39-year-old woman has been referred to the endocrine clinic with suspected acromegaly in December 2019. Surgery for benign ovarian cyst, endometriosis, amenorrhoea, unsuccessful in vitro fertilisations were present in her medical history. She complain...

ea0084op-02-07 | Oral Session 2: Pregnancy | ETA2022

Use of levothyroxine for euthyroid women with positive thyroid antibodies and infertility: Results of thesis (treatment of hypothyroidism in europe by specialists: an international survey)

Negro Roberto , Hegedus Laszlo , Attanasio Roberto , Nagy Endre V. , Papini Enrico , Zarkovic Milos , Perros Petros

Objectives: The use of levothyroxine (LT4) treatment aiming to improve fertility in euthyroid women with positive thyroid peroxidase antibodies (TPOAb), is not supported by the available evidence, however the extent to which this is applied in clinical practice is unknown. The aim of the study was to document the demographic, work-related characteristics, and therapeutic choices of European physicians in the case of euthyroid infertile women positive for TPOAb.<p class="ab...

ea0084ps1-02-12 | Hypothyroidism | ETA2022

Characteristics of specialists delivering clinical care for hypothyroidism in eupope: the “THESIS” study (treatment of hypothyroidism in europe by specialists: an international survey)

Zarkovic Milos , Attanasio Roberto , Hegedus Laszlo , V. Nagy Endre , Negro Roberto , Papini Enrico , Perros Petros

Objectives: Some hypothyroid patients are critical of their care, although this appears to vary between countries. The quality of thyroid care delivered, and the perceived patient experience may be influenced by characteristics of specialists such as age, sex, experience, and workplace setting. Here, we aimed to explore geographical differences in thyroid specialist characteristics.Methods: THESIS is a large European questionnaire survey of thyroid speci...

ea0014p358 | (1) | ECE2007

Water purification technology reduces iodine content of drinking water and contributes to iodine deficiency

Samson Laszlo , Czegeny Ildiko , Nagy Endre V , Mezosi Emese , Erdei Annamaria

Drinking water is the major natural source of iodine in many European countries. In the present study, we examined possible sites of iodine loss during the usual water purification process. Water samples from 6 sites during the technological process were taken and analyzed for iodine content. Under laboratory circumstances, prepared iodine in water solution has been used as a model to test the effect of the presence of chlorine. Samples from the purification sites revealed tha...

ea0081ep961 | Thyroid | ECE2022

Use of thyroid hormone in hypothyroid and euthyroid patients. the THESIS questionnaire survey in spain

Carlos Galofre Juan , Attanasio Roberto , Hegedus Laszlo , Nagy Endre V. , Negro Roberto , Papini Enrico , Perros Petros , Diez Juan Jose

Background: Hypothyroidism is one of the most frequent conditions in endocrinology. Despite of that fact, indications for treatment differ among specialists in Spain.Aims: To identify attitudes of Spanish endocrinologists in the use of levothyroxine (LT4) therapy and the management of hypothyroidism.Methods: The members of the Sociedad Española de Endocrinología y Nutrición (Spanish Society of Endocrinology ...

ea0084ps2-07-64 | Graves’ Disease 1 | ETA2022

The effect of glucocorticoids on hyaluronan production of orbital fibroblasts

Galgoczi Erika , Katko Monika , Erdei Annamaria , Bodor Miklos , Ujhelyi Bernadett , Steiber Zita , Gyory Ferenc , V. Nagy Endre

Objectives: Glucocorticoids (GCs) are the first line therapy in moderate to severe, active thyroid eye disease (TED). While their beneficial immunosuppressive effects are well known, direct connective tissue effects are less characterized. The accumulation of extracellular matrix component hyaluronan (HA) and increased proliferation rate of fibroblasts are hallmarks connective tissue changes in TED. We examined the effect of methylprednisolone (MP), prednisolone (P), hydrocort...

ea0063p719 | Pituitary and Neuroendocrinology 2 | ECE2019

Control of hyperglycemia in a young male patient with gigantism during transition: a case report

Berta Eszter , Lengyel Inez Mercedesz , Halmi Sandor , Puskas Istvan , Felszeghy Enikő , Balogh Zoltan , Nagy Endre V , Bodor Miklos

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...

ea0063p781 | Thyroid 2 | ECE2019

Iodine and selenium status in adult PKU

Sumanszki Csaba , Kiss Erika , Simon Erika , Galgoczi Erika , Soos Aron , Patocs Attila , Kovacs Bela , Nagy Endre V , Reismann Peter

Background: The standard, lifelong therapy of phenylketonuria (PKU) is natural protein-restricted diet completed with Phenylalanine (Phe)-free L-amino acid mixtures that provide the daily necessary micronutrients, such as iodine and selenium. Our main objective in this study was to assess the iodine and selenium status of patients with PKU, based on their adherence to the low-Phe diet, compared to a healthy control group. Secondly, we aimed to asses whether adherence to therap...