Searchable abstracts of presentations at key conferences in endocrinology

ea0037oc9.1 | Adrenal 2 | ECE2015

Effects of dexamethasone and adrenocorticotropin on circulating microRNA expression in humans

Igaz Ivan , Nyiro Gabor , Nagy Zoltan , Perge Pal , Toth Miklos , Racz Karoly , Igaz Peter , Patocs Attila

Objective: MicroRNAs are short non-protein coding RNA molecules involved in the regulation of numerous homeostatic processes via modulating gene expression. There are some data that the expression of microRNA might be modulated by hormones, but the interaction of hormones and circulating microRNAs of adrenocortical origin is mostly unknown.Methods: The expression of six selected circulating microRNAs (hsa-miR-27a, hsa-miR-125b-2, hsa-miR-200b, hsa-miR-21...

ea0022p833 | Thyroid | ECE2010

Is there a need to constitute laboratory- and/or region-specific reference ranges for the screening of thyroid disorders?

Horvath Dora , Toldy Erzsebet , Locsei Zoltan , Nagy Rita , Kovacs Gabor L , Szabolcs Istvan

Usually, the first laboratory marker for thyroid disorders is TSH. FT4 and FT3 must not be measured unless TSH is out of the reference range. However, the reference range for TSH (and for free thyroid hormones) given by the manufacturers of immunoassays may be not completely valid for screening in iodine-deficient areas and among hospitalized patients either.Aim: Our aim was to constitute specific TSH, FT4, FT3...

ea0063p719 | Pituitary and Neuroendocrinology 2 | ECE2019

Control of hyperglycemia in a young male patient with gigantism during transition: a case report

Berta Eszter , Lengyel Inez Mercedesz , Halmi Sandor , Puskas Istvan , Felszeghy Enikő , Balogh Zoltan , Nagy Endre V , Bodor Miklos

Introduction: In acromegaly GH excess leads to impaired insulin sensitivity with an alteration of beta-cell function. The consequent hyperglycemia leads to a further increased cardiovascular risk and mortality.Case report: A 16 years old patient was first referred to the Department of Pediatrics in 2014 with accentuated growth since the age of 10. The reason of the first referral was a sport injury (head trauma during playing basketball). Sella MRI depic...

ea0041gp114 | Endocrine Tumours | ECE2016

Proteomic and pathway analysis of adrenocortical cancer in an in vivo xenograft study

Nagy Zoltan , Baghy Kornelia , Hunyadi-Gulyas Eva , Decmann Abel , Kovalszky Ilona , Medzihradszky Katalin , Racz Karoly , Patocs Attila , Igaz Peter

Background: Few effective medical treatment options are available for adrenocortical carcinoma (ACC). Intensive efforts are therefore going on for exploring novel pathways and treatment targets.Objective: To perform a proteomic and pathway analysis on a 9-cisRA (9-cis retinoic acid) and mitotane-treated ACC xenograft model.Methods: 43 male SCID mice xenografted with NCI-H295R cells were treated in four groups (i. control, ii. 5 mg/...

ea0037gp.29.04 | Endocrine tumours and neoplasia – Adrenal Tumour | ECE2015

Synergistic action of 9-cis retinoic acid and mitotane in a H295R adrenocortical cancer xenograft model

Nagy Zoltan , Baghy Kornelia , Szabo Peter M , Kovalszky Ilona , Perge Pal , Patocs Attila , Racz Karoly , Igaz Peter

Background: Current drug treatment options for adrenocortical carcinoma (ACC) are rather limited and intensive efforts are going on to find novel effective agents. In our previous functional genomics study, retinoid signalling via the retinoid X receptor (RXR) was identified as a major pathogenic pathway in ACC and we have demonstrated the in vitro activity of 9-cis retinoic acid (9-cisRA) acting via the RXR on NCI-H295R cells and also found that 9-cisRA has antitumou...

ea0049gp3 | Adrenal 1 | ECE2017

Exosomal hsa-miR-483-5p and hsa-miR-101 are potential minimally invasive biomarkers of adrenocortical carcinoma

Perge Pal , Butz Henriett , Pezzani Raffaele , Bancos Irina , Nagy Zoltan , Decmann Abel , Luconi Michaela , Mannelli Massimo , Buzas Edit Iren , Toth Miklos , Boscaro Marco , Patocs Attila , Igaz Peter

Background: Extracellular vesicles (exosomes, microvesicles) shed from tumor cells containing microRNAs can be exploited as markers of malignancy. The preoperative diagnosis of adrenocortical malignancy is difficult and microRNAs have proved useful in the diagnosis of many tumors, including adrenocortical cancer (ACC), but there have no studies to date on extracellular vesicle associated microRNAs in ACC.Aim: To evaluate the diagnostic potential of extra...

ea0035oc10.1 | Endocrine Tumours | ECE2014

Blood-borne and tissue microRNAs in adrenocortical tumours: affected pathways and diagnostic relevance

Igaz Peter , Szabo Diana Rita , Zsippai Adrienn , Szabo Peter M , Nagy Zoltan , Toth Miklos , Luconi Michaela , Mannelli Massimo , Patocs Attila , Racz Karoly

Background: The differential expression of tissue microRNAs in benign and malignant adrenocortical tumours has been described in several studies including ours. Novel data show that microRNAs are also present in the bloodstream and can be exploited as minimally invasive markers of malignancy.Objective: To analyze the microRNAs expressed in different studies by an in silico approach and to establish the molecular pathways affected. Furthermore, circulatin...

ea0056p81 | Adrenal medulla | ECE2018

A retrospective audit on the peri-operative management of phaeochromocytomas: “Phenoxybenzamine or Doxazosin”?

Ni Lee Yun , Casey Edel , Baig Mirza Asfand , Wickramsinghe Sasala , Jones Stuart , Nagy Zoltan , Syed Imran , Kelkar Anand , Stojanovic Nemanja , Pittathankal Antony , Tanday Raj , Nikookam Khash

Phaeochromocytomas are rare catecholamine secreting tumours with an incidence of 1:4500–1:1700 in the United States. Doxazosin and Phenoxybenzamine are alpha-1 selective and non-selective alpha blockers respectively which are commonly used to treat this condition peri-operatively. There are no randomized controlled studies comparing the effectiveness of these two medications. However, there are retrospective studies comparing these two medications; some favouring alpha-1 ...