Searchable abstracts of presentations at key conferences in endocrinology

ea0003p274 | Steroids | BES2002

What value do cortisol measurements provide in monitoring metyrapone therapy?

Wieringa G , Naing S , Perry L , Anderson J , Wiener K , Burrows G , Warburton R , Kane J , Trainer P

Metyrapone is a potent inhibitor of the conversion of 11-deoxycortisol (11-DOC) to cortisol and is used in the treatment of Cushing's syndrome. This study has assessed the clinical significance of 11-DOC cross-reaction in five serum cortisol assays provided on automated immunoassay analysers. Cross-reaction was determined from the linear regression of increase in measured cortisol against increasing levels of 11-DOC (0, 1590, 4310, 6490, 7040 nmol/L) added to a serum pool. In ...