Endocrine Abstracts

Background: Acromegaly is due to excess Growth hormone (GH) production, usually as result of pituitary adenoma. The diagnosis is often preceded by around 5 years of active but unrecognized disease. Clinical expression of the disease in each patient depend on the levels of GH and Insulin-like Growth Factor-1 (IGF-1), age, tumor size, and the delay in diagnosis. Successful remission after Trans-sphenoidal surgery (TSS) is reported to be found in 52.5% of cases in the developed c...

Introduction: Graves’ disease and Hashimoto’s thyroiditis are the two autoimmune spectrum of thyroid disease. Cases of conversion from hyperthyroidism to hypothyroidism have been reported but conversion from hypothyroidism to hyperthyroidism is very rare although reported. We report a case of hypothyroidism that converted to a hyperthyroid state needing treatment.Case report: A 36 years old female presented with a 3 months history of easy fatig...

Introduction: Nonmedullary carcinoma of thyroid is most common of thyroid carcinoma with familial predisposition and very low incidence.We describe cases of three brothers with familial nonmedullary thyroid carcinoma diagnosed over a span of six years clinical follow up.Case: 58 years male with swelling in neck for 5 days. On examination he had left thyroid nodule. Ultrasound thyroid showed multinodular goiter while fine needle aspiration cytology (FNAC)...

Introduction: Hypothyroidism is a common endocrine disorder worldwide. Its treatment is with oral thyroxine, but when this route cannot be utilised then intravenous thyroxine is an alternate but not available in some countries so rectal thyroxine administration can be used but clinical experience is lacking.Case report: This is a case of a 55-years-old Pakistani male known case of hypothyroidism since July 2007 and was maintaining normal TSH and FT4...

Introduction: A thyroid ultrasound scan is recommended in the assessment of any suspected thyroid nodule. The ultrasound characteristics of nodules have been shown to be useful in assessing their malignant potential. The aim of this study is to determine diagnostic validity of thyroid ultrasound in differentiating benign and malignant thyroid nodule.Material and Methods: It was cross-sectional study, conducted at XXXX Hospital from August 2011 to July 20...

Background: Primary hyperparathyroidism (PHPT) is characterized by abnormal regulation of PTH secretion by calcium. The most common clinical presentation of PHPT is asymptomatic (80% cases), followed less likely by the classical symptoms of bones, stones, abdominal moans, and psychic groans. The diagnosis of PHPT is usually first suspected because of the finding of an elevated serum calcium concentration along with a rise in Parathyroid hormone (PTH) level. Serum phosphorus le...

BackgroundPituitary gonadotroph adenomas are common but very rarely do they secrete biologically active luteinizing hormone (LH) and follicle-stimulating hormone (FSH). There have been case studies reporting high sex hormones (testosterone/estrogen) in the presence of high or normal LH and FSH.Case presentationHere we report two cases who presented with visual disturbance and headache at a tertiary care hospi...

Introduction: Diagnosis of sub acute thyroiditis is readily considered in a patient presenting with classical history and characteristic clinical features. Confirmation of diagnosis is based on particular set of laboratory investigations and supported by characteristic imaging findingsof Tc-99 scan. However, prescence of sub acute thyroiditis with normal thyroid scintigraphy findings is exceedingly rare.Case report: 51 years old postmenopausal female wit...

Introduction: Ectopic thyroid tissue is the most common form of thyroid dysgenesis. But primary malignant transformation in ectopic thyroid tissue is quite a rare entity, with follicular malignancy being the dominant form at ectopic sites. Very infrequently, malignant ectopic thyroid tissue can present with metastasis to lymph nodes. But we report a case of malignant ectopic thyroid tissue over manubrium sterni with distant metastasis.Case presentation: ...

Material and methods: Retrospective review of patients with thyroid cancer at our hospital from 1999 to 2011 was done.Results: Mean age at presentation was 44±17 years with female to male ratio of 2.1:1. Patients were followed for mean of 6.45 and median of 6 years. Out of 206 patients, 158 had differentiated thyroid carcinoma. Most common variant was papillary (n=130, 63.10%) followed by follicular carcinoma (n=22, 8.73%). 6 (2.91...