Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1212 | Obesity | ICEECE2012

Regulation of adiponectin by free fatty acids in lean and obese subjects

Kim K. , Nam S. , Ahn C. , Yu J. , Kim K. , Cha B. , Lee H. , Richelsen B.

Objective: To evaluate the effects of free fatty acids (FFAs) on the regulation of plasma and adipose tissue mRNA adiponectin expression in lean and obese subjects.Methods: Seven obese men (31.3±1.1 kg/m2) and eight lean men (21.3±0.4 kg/m2) were studied. Subjects received an Intralipid 20% infusion over 180-min with sodium heparin. Blood sampling and abdominal subcutaneous adipose tissue biopsy were taken before and after...

ea0029p1226 | Obesity | ICEECE2012

Curcumin inhibits the upregulation of cathepsin L by palmitate in fat

Yoo J. , Lee Y. , Kim J. , Kang S. , Nam J. , Park J. , Ahn C. , Song Y. , Kim K.

Objective: Cathepsin L can control adipogenesis and relate to acute coronary syndrome. However, it is not clear whether cathepsin L can be affected by saturated fatty acid and decrease by curcumin. We examined the hypothesis that palmitate upregulates cathepsin L expression in adipose tissue and curcumin can be block that effect.Methods: 3T3-L1 cells were fully differentiated for 8 to 10 days and treated with palmitate, LPS, IL6, TNF-α, IL6 neutrali...