Searchable abstracts of presentations at key conferences in endocrinology

ea0041oc2.1 | Receptors & Signalling | ECE2016

3-T1AM signaling in the rat thyrocyte cell line PCCL3

Schanze Nancy , Khajavi Noushafarin , Mergler Stefan , Biebermann Heike , Kohrle Josef

The endogenous decarboxylated thyroid hormone (TH) metabolite 3-Iodothyronamine (3-T1AM) exerts partially TH antagonistic effects in rodents and was shown to suppress the hypothalamic pituitary thyroid axis in rats after single dose application. Therefore, it might play a role in maintaining TH homoeostasis. Among the molecular targets of 3-T1AM are G protein-coupled receptors like the trace amine associated receptor 1 (TAAR1) and adrenergic receptors. Furthermore, 3-T1AM was ...